Anti-histone Antibody-Cytokine Fusion Protein, IL2-IgG (NHS76) (CAT#: ACFP-SH114)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-histone IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the histone as well as the biological activity of IL2. The recombinant IL-2/anti-DNA fusion protein, was developed with the aim of maximizing immunomodulatory action and clinical efficacy at minimal vascular toxicity, despite treatment at optimal doses. The analysis of peripheral leukocytes showed a strong and transitory increase early after infusion of IL-2/anti-DNA fusion protein. lymphocytes responded readily while the effects on monocytes were less pronounced, and no significant changes were observed to neutrophils. This immunocytokine was designed for treating necrotic tumor.
Specific Inquiry
Specifications
- Target
- Histone
- Molecule Class
- IL2-IgG1
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- NHS76
- Related Disease
- Necrotic tumor
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- Histones; histone HI; histone H3; histone H2B; histone H4; histone H2A
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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