Anti-DNA-histone complexes Immunocytokine, IgG (NHS76)-IL2-LT (ACFP-SH170)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-DNA-histone complexes IgG to IL2 and LT. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the DNA-histone complexes as well as the biological activity of IL2 and LT. NHS-IL2-LT was shown to have near normal biological activity in vitro by using T-cell lines expressing the high-affinity IL2 receptor, but little or no activity by using cell lines expressing only the intermediate IL2 receptor. NHS-IL2-LT showed low toxicity and efficacy as a single agent in vivo, is currently tested in a phase 1 clinical trial in patients with locally advanced solid tumors or B-cell non-Hodgkin lymphoma. This immunocytokine was designed for treating necrotic tumor.      

DNA-histone complexes
Molecule Class
Species Reactivity
Expression Host
Related Disease
Necrotic tumor
Cytokines 1
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Cytokines 2
Cytokines 2 Description
Lymphotoxin (previously known as tumor necrosis factor-beta) is a lymphokine cytokine. It is a protein that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them. It is also known to be required for normal development of Peyer's patches. Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts produced. The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs.
Cytokine 2 Species
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Alternative Names
Histones; histone HI; histone H3; histone H2B; histone H4; histone H2A

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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