Anti-Human IL23A Recombinant Antibody (Brazikumab) (CAT#: TAB-008ML)

Recombinant monoclonal antibody to IL23A. Brazikumab is a human monoclonal antibody that can be potentially used in the treatment of Crohn's disease (CD).


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  • Tested Data
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PK

Figure 1 Atients receiving MEDI2070 had greater reductions in serum IL22 levels than did patients receiving placebo.

Figure 1 Atients receiving MEDI2070 had greater reductions in serum IL22 levels than did patients receiving placebo.

Percent change from baseline in serum IL22 levels in MEDI2070 and placebo groups (A) and percentage of patients with clinical response (B) and with clinical remission (C) over time, by baseline serum IL22 levels. Error bars represent median absolute deviation (MAD).

Sands, B. E., Chen, J., Feagan, B. G., Penney, M., Rees, W. A., Danese, S.,... & Li, J. (2017). Efficacy and safety of MEDI2070, an antibody against interleukin 23, in patients with moderate to severe Crohn’s disease: a phase 2a study. Gastroenterology, 153(1), 77-86.

PK

Figure 2 The serum MEDI2070 concentration levels between responders and nonresponders at weeks 8, 12, and 24.

Figure 2 The serum MEDI2070 concentration levels between responders and nonresponders at weeks 8, 12, and 24.

Individual concentration of MEDI2070 by CDAI response (A, B) and CDAI remission (C, D) during the double-blind phase (A, C) and the open-label extension phase (C, D).

Sands, B. E., Chen, J., Feagan, B. G., Penney, M., Rees, W. A., Danese, S.,... & Li, J. (2017). Efficacy and safety of MEDI2070, an antibody against interleukin 23, in patients with moderate to severe Crohn’s disease: a phase 2a study. Gastroenterology, 153(1), 77-86.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgG2, λ
  • Specificity
  • Human IL23A
  • Species Reactivity
  • Human
  • Applications
  • ELISA, IHC, FC, IP, IF, Inhib, PK
  • Conjugate
  • Unconjugated
  • CAS
  • 1610353-18-8
  • Generic Name
  • Brazikumab
  • UNII
  • 50EI9G8Q6U
  • Related Disease
  • Crohn's disease (CD)

Product Property

  • Purity
  • > 95% as determined by SDS-PAGE
  • Storage
  • Store at -20°C for long-term storage. Avoid freeze/thaw cycles.

Applications

  • Application Notes
  • The IL23A antibody has been reported in applications of ELISA, IHC, FC, IP, IF, Inhib, PK.

Target

  • Alternative Names
  • Interleukin 23 subunit alpha; IL-23A; IL-23 subunit p19; IL23p19

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Brazikumab"

Afuco™ Anti-IL23A ADCC Recombinant Antibody (Brazikumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL23A. Brazikumab is a human monoclonal antibody that can be potentially used in the treatment of Crohn's disease (CD).

See other products for "IL23A"

Single-domain Antibody

CAT Product Name Application Type
NAB-1953-VHH Recombinant Anti-human IL23A VHH Single Domain Antibody WB, IP, ICC, FC, FA Llama VHH
TAB-005LC-VHH Anti-human IL23A Recombinant Antibody (119A3) (TAB-005LC-VHH) ELISA Single domain antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-607LC Anti-human IL23A Recombinant Antibody (E11E7Chimera) (TAB-607LC) ELISA, Neut, FuncS Chimeric antibody (rat/human)
TAB-607LC-S(P) Anti-human IL23A scFv Fragment (E11E7Chimera) ELISA Chimeric antibody (rat/human)
TAB-607LC-F(E) Anti-human IL23A Fab Fragment (E11E7Chimera) ELISA Chimeric antibody (rat/human)

Humanized Antibody

CAT Product Name Application Type
TAB-616LC Anti-human IL23A Recombinant Antibody (A3M0) (TAB-616LC) ELISA, FC, Inhib, FuncS Humanized antibody
TAB-617LC Anti-human IL23A Recombinant Antibody (A3M1) (TAB-617LC) ELISA, FC, Inhib Humanized antibody
TAB-618LC Anti-human IL23A Recombinant Antibody (A3N1) (TAB-618LC) ELISA, FC, Inhib Humanized antibody
TAB-605LC-S(P) Anti-human IL23A scFv Fragment (FM303) ELISA Humanized antibody
TAB-608LC-S(P) Anti-human IL23A scFv Fragment (21-4) ELISA Humanized antibody

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-875 Afuco™ Anti-IL23A ADCC Recombinant Antibody (Tildrakizumab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody
AFC-TAB-620LC Afuco™ Anti-IL23A ADCC Recombinant Antibody (Risankizumab), ADCC Enhanced ELISA ADCC enhanced antibody
AFC-TAB-008ML Afuco™ Anti-IL23A ADCC Recombinant Antibody (Brazikumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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