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    BV421-BF2*04:01/Gallus gallus FUS (IDWFDGKD) MHC Tetramer (CAT#: MHC-LC1744)

    This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of FUS-derived peptide of IDWFDGKD covering 319-326 and BF2*04:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

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    • Size:
    Custom Production

    MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

    Peptide Sequence *:
    Allele Requested *:
    Antigen Species:
    Antigen Molecule:
    Sequence Position:
    Form Requested *:
    Conjugation *:
    Size *:
    Comments:

    Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-251 MG
    Figure 1 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8784/if_selected.jpg
    Figure 2 IF staining of human cell line U-2 OS
    Figure 2 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/33036/1894_G5_1_selected.jpg
    Normal Tissue
    Figure 3 IHC staining of human fallopian tube
    Figure 3 IHC staining of human fallopian tube
    (Immunohistochemical staining of human fallopian tube shows strong nuclear positivity in glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/8784/22362_A_9_7_selected.jpg
    Figure 4 Kidney
    Figure 4 Kidney
    (Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/33036/126298_A_8_5.jpg
    Figure 5 Testis
    Figure 5 Testis
    (Leydig cells Staining: High Intensity: Strong Quantity:>75% Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Peritubular cells Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity:>75% Round or early spermatids Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: High Intensity: Strong Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/33036/126298_A_6_6.jpg
    Figure 6 Skin
    Figure 6 Skin
    (Cells in basal layer Staining: High Intensity: Strong Quantity:>75% Cells in granular layer Staining: High Intensity: Strong Quantity:>75% Cells in spinous layer Staining: High Intensity: Strong Quantity:>75% Endothelial cells Staining: High Intensity: Strong Fibrohistiocytic cells Staining: High Intensity: Strong Hair follicles Staining: High Intensity: Strong Quantity:>75% Langerhans cells Staining: High Intensity: Strong Quantity:>75% Lymphocytes Staining: High Intensity: Strong Melanocytes Staining: High Intensity: Strong Quantity:>75% Vascular mural cells Staining: High Intensity: Strong)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/33036/126298_B_8_1.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/33036/126298_A_9_8.jpg
    Figure 8 Colon
    Figure 8 Colon
    (Endocrine cells Staining: High Intensity: Strong Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Fibroblasts Staining: High Intensity: Strong Goblet cells Staining: High Intensity: Strong Quantity:>75% Mucosal lymphoid cells Staining: High Intensity: Strong)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/33036/126298_A_9_3.jpg
    Figure 9 Liver
    Figure 9 Liver
    (Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/33036/126298_A_7_4.jpg
    RNA Expression
    Figure 10 RNA cell line category: Low cell line specificity
    Figure 10 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000089280-FUS

    Specifications

    • Allele
    • BF2*04:01
    • Class
    • Class I
    • MHC Species
    • Chicken
    • Antigen
    • FUS/TLS
    • Antigen Species
    • Gallus gallus
    • Peptide
    • IDWFDGKD
    • Range
    • 319-326
    • Conjugate
    • BV421
    • Application
    • FCM

    Target

    • Antigen Introduction
    • This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
    • Alternative Names
    • FUS; FUS RNA binding protein; FUS/TLS

    Downloads

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    CAT Product Name Application Type
    MOB-4041z Mouse Anti-FUS Recombinant Antibody (clone 44H2) WB, ELISA, IF, IHC, IP Mouse IgG1
    MRO-0614-CN Rabbit Anti-FUS Recombinant Antibody (clone CBACN-233) WB, IF, IHC, FC Rabbit IgG
    VS3-CJ906 Rabbit Anti-FUS Recombinant Antibody (VS3-CJ906) WB, ICC, IF, IHC, FC Rabbit IgG

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