Recombinant Anti-CD20 × Anti-CD3 Bispecific Antibody (CrossMab)
CAT#: CROSS-L025
Recombinant Anti-CD20 × Anti-CD3 Bispecific Antibody (CrossMab) has been generated by applying the Crossmab format to generate an IgG shaped entity that binds each ligand with one arm. This BsAb is capable of targeting the tumor and recruiting T effector cells via binding to the CD3 subunit of the T cell receptor complex. It was designed for the treatment of Non-Hodgkin`s lymphoma and other CD20+ B-cell malignancies.
Specifications
- Target
- CD20 & CD3
- Type
- CrossMab
- Species Reactivity
- Human
- Target 1
- CD20
- Host Species 1
- Mouse
- Target 2
- CD3
- Host Species 2
- Mouse
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Non-Hodgkin`s lymphoma and other CD20+ B-cell malignancies
Target
- Target 1
- CD20
- Gene ID
- 931
- UniProt ID
- A0A024R507
- Alternative Names
- MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16; B-lymphocyte antigen CD20; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1
- Target 2
- CD3
- Gene ID
- 916
- UniProt ID
- P07766
- Alternative Names
- CD3E; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
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Robust Cytotoxicity Induction
Our lab used this product to evaluate T cell mediated cytotoxicity against various CD20 positive cell lines. The antibody demonstrated potent activity at low concentrations, and the results were highly reproducible across different donor T cell batches in our experiments.
Stable Heterodimer Structure
The structural integrity of this CrossMab is impressive. We performed stability tests over several weeks, and the molecule remained intact without significant degradation. This reliability is crucial for our long-term culture experiments involving blood cancer models.
Q&As
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What is the mechanism of action for this bispecific antibody in research?
A: This product functions by bridging T cells and CD20-expressing tumor cells. One arm binds to the CD20 antigen on B cells, while the other binds to the CD3 subunit of the T cell receptor complex. This physical proximity activates the T cells to exert cytotoxic effects on the target tumor cells.
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Does this antibody retain the structure of a standard IgG molecule?
A: Yes, this bispecific antibody is generated using CrossMab technology to create an IgG-shaped molecule. This design allows it to maintain structural similarities to natural antibodies, potentially offering better stability and pharmacokinetic properties in your research models compared to smaller antibody fragments.
View the frequently asked questions answered by Creative Biolabs Support.
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