Recombinant Anti-CTLA4 × Anti-PD-1 Bispecific Antibody (Triplebody) (CAT#: TRIAB-MZ012)

This bispecific antibody contains a first antigen binding moiety that specifically binds an epitope on human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and a second antigen binding moiety that specifically binds an epitope on a human programmed death 1 (PD-1) receptor, which can provide some pharmaceutical compositions as well as methods and kits for treating cancer. It is also capable of blocking both CTLA-4 and PD-1 pathways on T cell activation and resulting in enhanced T cell proliferation subsequently.


Specific Inquiry
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  • Conjugation:
  • Datasheet
  • MSDS
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Specifications

  • Target
  • CTLA4 & PD-1
  • Type
  • Triplebody
  • Species Reactivity
  • Human
  • Target 1
  • CTLA4 (Cytotoxic T-lymphocyte-associated antigen 4)
  • Host Species 1
  • Human
  • Target 2
  • PD-1 (Programmed death 1)
  • Host Species 2
  • Human
  • Application
  • FC
  • Related Disease
  • Fibrosarcoma, colorectal cancer, renal cancer, melanoma

Target

  • Target 1
  • CTLA4 (Cytotoxic T-lymphocyte-associated antigen 4)
  • Alternative Names
  • CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; insulin-dependent diabetes mellitus 12; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
  • Target 2
  • PD-1 (Programmed death 1)
  • Alternative Names
  • PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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