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    Recombinant Anti-CTLA4 × Anti-PD-1 Bispecific Antibody (Triplebody)

    CAT#: TRIAB-MZ012

    This bispecific antibody contains a first antigen binding moiety that specifically binds an epitope on human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and a second antigen binding moiety that specifically binds an epitope on a human programmed death 1 (PD-1) receptor, which can provide some pharmaceutical compositions as well as methods and kits for treating cancer. It is also capable of blocking both CTLA-4 and PD-1 pathways on T cell activation and resulting in enhanced T cell proliferation subsequently.

    Specifications

    • Target
    • CTLA4 & PD-1
    • Type
    • Triplebody
    • Species Reactivity
    • Human
    • Target 1
    • CTLA4 (Cytotoxic T-lymphocyte-associated antigen 4)
    • Host Species 1
    • Human
    • Target 2
    • PD-1 (Programmed death 1)
    • Host Species 2
    • Human
    • Application
    • FC
    • Related Disease
    • Fibrosarcoma, colorectal cancer, renal cancer, melanoma

    Target

    • Target 1
    • CTLA4 (Cytotoxic T-lymphocyte-associated antigen 4)
    • Alternative Names
    • CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; insulin-dependent diabetes mellitus 12; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
    • Target 2
    • PD-1 (Programmed death 1)
    • Alternative Names
    • PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2
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    Datasheet

    Datasheet - TRIAB-MZ012.pdf

    MSDS

    MSDS - TRIAB-MZ012.pdf

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