Recombinant Anti-EGFR × Anti-IGF-1R Bispecific Antibody (Triplebody) (CAT#: TRIAB-MZ013)
This bispecific antibody shows an improved downregulation EGFR compared to the parent antibody. It is capable of downregulating both EGFR and IGFlR as well as inhibiting both EGFR- and IGFlR- signaling pathways.
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Specifications
- Target
- EGFR & IGF-1R
- Type
- Triplebody
- Species Reactivity
- Human
- Target 1
- EGFR
- Host Species 1
- Human
- Target 2
- IGF-1R
- Host Species 2
- Human
- Application
- FC, ELISA
- Related Disease
- Non-small-cell lung cancer (NSCLC)
Target
- Target 1
- EGFR
- Gene ID
- 1956
- UniProt ID
- P00533
- Alternative Names
- EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
- Target 2
- IGF-1R
- Gene ID
- 3480
- UniProt ID
- P08069
- Alternative Names
- IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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