Recombinant Anti-FcαRI × Anti-HLA class II Bispecific Antibody (Tandem Diabody)
CAT#: TAND-L025
Recombinant Anti-FcαRI × Anti-HLA class II Bispecific Antibody (Tandem Diabody) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. Tandem Diabodies do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than tandem scFvs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with tandem scFvs. This BsAb can retarget of neutrophils to tumor cells. It was designed for the treatment of lymphoma.
Specifications
- Target
- FcαRI & HLA class II
- Type
- Tandem Diabody
- Species Reactivity
- Human
- Target 1
- FcαRI
- Host Species 1
- Human
- Target 2
- HLA class II
- Host Species 2
- Mouse
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Lymphoma
Target
- Target 1
- FcαRI
- Gene ID
- 2204
- UniProt ID
- P24071
- Alternative Names
- CD89; FcalphaRI; CTB-61M7.2
- Target 2
- HLA class II
- Gene ID
- 3123
- UniProt ID
- P01912
- Alternative Names
- HLA-DRB1; major histocompatibility complex, class II, DR beta 1; SS1; DRB1; DRw10; HLA-DRB; HLA-DR1B; DW2.2/DR2.2; HLA class II histocompatibility antigen, DR-1 beta chain; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; MHC class II antigen; human leucocyte antigen DRB1; lymphocyte antigen DRB1
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