Recombinant Anti-FcγRIII × Anti-CD33 × Anti-CD19 Bispecific Antibody (Triplebody) (CAT#: TRIAB-L002)
Recombinant Anti-FcγRIII × Anti-CD33 × Anti-CD19 Bispecific Antibody (Triplebody) has two parts targeting leukemic cells antigens and one targeting immune cells. This BsAb can induce potent antibody-dependent cellular cytotoxicity (ADCC) of two different AML-derived CD33- and CD19 double-positive cells and produce significantly stronger lysis than the mono targeting agent. It was designed for the treatment of acute myeloid leukaemia (AML).
Specific Inquiry
Specifications
- Target
- FcγRIII & CD33 & CD19
- Type
- Triplebody
- Species Reactivity
- Human
- Target 1
- FcγRIII
- Host Species 1
- Mouse
- Target 2
- CD33
- Host Species 2
- Mouse
- Host Species 3
- Mouse
- Application
- FC
- Related Disease
- Acute myeloid leukaemia (AML)
Target
- Target 1
- FcγRIII
- Gene ID
- 2214
- UniProt ID
- M9MML0
- Alternative Names
- FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA; low affinity immunoglobulin gamma Fc region receptor III-A; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RII
- Target 2
- CD33
- Gene ID
- 945
- UniProt ID
- P20138
- Alternative Names
- CD33; CD33 molecule; p67; SIGLEC3; SIGLEC-3; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3
- Gene ID
- 930
- UniProt ID
- P15391
Downloads
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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