Recombinant Anti-FcγRIII × Anti-HER2 Bispecific Antibody (Fab2)
CAT#: FAB-L014
Recombinant Anti-FcγRIII × Anti-HER2 Bispecific Antibody (Fab2) is composed of the Fab of the anti-CD16 monoclonal antibody and Fab of an antibody specific for erbB2. A linker is added between the two Fab. The bispecific antibody is somewhat smaller than a whole IgG, and therefore it clears from the blood naturally at a faster rate. This BsAb can retarget of NK cells to tumor cells. It was designed for the treatment of breast, ovary, colon, and lung cancers.
Specifications
- Target
- FcγRIII & HER2
- Type
- Fab2
- Species Reactivity
- Human
- Target 1
- FcγRIII
- Host Species 1
- Mouse
- Target 2
- HER2
- Host Species 2
- Mouse
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Breast, ovary, colon, and lung cancers
Target
- Target 1
- FcγRIII
- Gene ID
- 2214
- UniProt ID
- M9MML0
- Alternative Names
- FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA; low affinity immunoglobulin gamma Fc region receptor III-A; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RII
- Target 2
- HER2
- Gene ID
- 2064
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
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