Recombinant Anti-GD2 × Anti-FcγRIII Bispecific Antibody (Tandem Diabody)
CAT#: TAND-L026
Recombinant Anti-GD2 × Anti-FcγRIII Bispecific Antibody (Tandem Diabody) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. Tandem Diabodies do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than tandem scFvs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with tandem scFvs. This BsAb is capable of targeting the tumor and recruiting NK effector cells via binding to the FcγRIII subunit of the NK cells. It was designed for the treatment of neuroblastoma and osteosarcoma.
Specifications
- Target
- GD2 & FcγRIII
- Type
- Tandem Diabody
- Species Reactivity
- Human
- Target 1
- GD2
- Host Species 1
- Human
- Target 2
- FcγRIII
- Host Species 2
- Mouse
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Neuroblastoma and Osteosarcoma
Target
- Target 1
- GD2
- Alternative Names
- Ganglioside G2; GD2; Ganglioside
- Target 2
- FcγRIII
- Gene ID
- 2214
- UniProt ID
- M9MML0
- Alternative Names
- FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA; low affinity immunoglobulin gamma Fc region receptor III-A; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RIIIa; Fc-gamma RIII-alpha; igG Fc receptor III-2; Fc gamma receptor III-A; Fc-gamma receptor IIIb (CD16); neutrophil-specific antigen NA; Fc-gamma receptor III-2 (CD 16); immunoglobulin G Fc receptor III; Fc fragment of IgG, low affinity III, receptor for (CD16)
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for TAND-L026. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: FuncS, Inhib, IP, ELISA
Application: FC, IHC-Fr, IP, ELISA, Block
Application: Neut, IHC, Activ, FuncS, IF, ELISA
Application: FC
-3.jpg)
Application: IB, FC, ELISA, FuncS
Application: ELISA, FC, FuncS
Application: IF, ICC, WB, IHC-P, IP
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
