Recombinant Anti-HER2 × Anti-VEGF Bispecific Antibody (F(ab`)2, bH1-44)
CAT#: FAB-MZ006
This bispecific antibody can inhibit VEGF-induced proliferation of HUVEC cells and growth of BT474 cells. It is also capable of inhibiting HER2 and VEGF-mediated cell proliferation by blocking human VEGF binding to VEGFR1 as well as blocking HER2 activation.
Specifications
- Target
- HER2 & VEGF
- Type
- F(ab')2
- Expression Host
- CHO
- Species Reactivity
- Human
- Target 1
- HER2
- Host Species 1
- Human
- Target 2
- VEGF
- Host Species 2
- Human
- Purity
- >95% judged by SDS-PAGE under reducing condition
- Application
- FC
- Related Disease
- Cancer
Target
- Target 1
- HER2
- Alternative Names
- HER2; Epidermal growth factor receptor 2 (HER2)
- Target 2
- VEGF
- Alternative Names
- VEGF; Vascular endothelial growth factor
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Dual Mechanism Works Well
The concept of targeting the tumor cell and the microenvironment simultaneously is fascinating. We used this antibody to inhibit both HER2 signaling and VEGF-mediated endothelial cell proliferation, and the combined effect in our 3D culture model was very significant.
Useful For Microenvironment Study
This product is an excellent tool for dissecting the interplay between tumor growth and angiogenesis. We were able to visualize the disruption of vascular network formation in the presence of HER2 positive tumor spheroids using this bispecific antibody.
Q&As
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What is the dual mechanism of action for this HER2/VEGF antibody?
A: This bispecific antibody works by "double targeting": it targets HER2 on tumor cells to inhibit their proliferation and simultaneously targets VEGF in the tumor microenvironment to block angiogenesis. This dual approach allows researchers to study the combined effects of inhibiting tumor growth and blood supply.
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Can this antibody be used to study the tumor microenvironment?
A: Yes, it is an excellent tool for studying the interaction between the tumor and its microenvironment. By targeting VEGF, a key factor in angiogenesis, alongside the tumor antigen HER2, you can investigate how suppressing vascular formation influences tumor progression and survival in your experimental models.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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