Recombinant Anti-IL-17A × Anti-IL-23 Bispecific Antibody (Tandem Diabody)
CAT#: TAND-L018
Recombinant Anti-IL-17A × Anti-IL-23 Bispecific Antibody (Tandem Diabody) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. Tandem Diabodies do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than tandem scFvs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with tandem scFvs. This BsAb is capable of simultaneous blocking two cytokines and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It was designed for the treatment of autoimmune disorders, cancer and neoplastic diseases.
Specifications
- Target
- IL-17A & IL-23
- Type
- Tandem Diabody
- Species Reactivity
- Human
- Target 1
- IL-17A
- Host Species 1
- Human
- Target 2
- IL-23
- Host Species 2
- Human
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Autoimmune disorders,Cancer/neoplastic diseases
Target
- Target 1
- IL-17A
- Gene ID
- 3605
- UniProt ID
- Q16552
- Alternative Names
- IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
- Target 2
- IL-23
- Gene ID
- 51561
- UniProt ID
- Q9NPF7
- Alternative Names
- P19; SGRF; IL-23; IL-23A; IL23P19
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