Recombinant Anti-PD-1 & Anti-TIM-3 Bispecific Antibody (Fab₂ is composed of the Fab of the anti-PD-1 monoclonal antibody and Fab of an antibody specific for TIM-3. A linker is added between the two Fab. The bispecific antibody is somewhat smaller than a whole IgG and therefore it can be cleared from the blood naturally at a faster rate. It was designed for the treatment of chronic immune conditions and cancers.

Specifications

Target
PD-1 & TIM-3

Type
Fab₂

Species Reactivity
Human

Target 1
PD-1

Host Species 1
Mouse

Target 2
TIM-3

Host Species 2
Rat

Application
FuncS, Promising therapeutic agent

Related Disease
Chronic immune conditions, cancer

Target

Target 1
PD-1

Gene ID
5133

UniProt ID
Q15116

Alternative Names
PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2

Target 2
TIM-3

Gene ID
84868

UniProt ID
Q8TDQ0

Alternative Names
TIM3; CD366; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2

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