Recombinant Anti-PSCA × Anti-CD8 Bispecific Antibody (Tandem Diabody)
CAT#: TAND-L014
Recombinant Anti-PSCA × Anti-CD8 Bispecific Antibody (Tandem Diabody) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. Tandem Diabodies do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than tandem scFvs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with tandem scFvs. This BsAb can retarget of T cells to tumor cells. It was designed for the treatment of prostate cancer.
Specifications
- Target
- PSCA & CD8
- Type
- Tandem Diabody
- Species Reactivity
- Human
- Target 1
- PSCA
- Host Species 1
- Human
- Target 2
- CD8
- Host Species 2
- Human
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Prostate cancer
Target
- Target 1
- PSCA
- Gene ID
- 8000
- UniProt ID
- D3DWI6
- Alternative Names
- PSCA; prostate stem cell antigen; PRO232
- Target 2
- CD8
- Gene ID
- 925
- UniProt ID
- P01732
- Alternative Names
- CD8A; CD8a molecule; CD8; MAL; p32; Leu2; T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen; T cell co-receptor; OKT8 T-cell antigen; T-cell antigen Leu2; Leu2 T-lymphocyte antigen; CD8 antigen, alpha polypeptide (p32); T-lymphocyte differentiation antigen T8/Leu-2
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