Recombinant Anti-Tweak × Anti-IL17 Bispecific Antibody (CrossMab) (CAT#: CROSS-L043)
Recombinant Anti-Tweak × Anti-IL17 Bispecific Antibody (CrossMab) has been generated by applying the Crossmab format to generate an IgG shaped entity that binds each ligand with one arm. This BsAb is capable of inhibiting two cytokines and a combined blockade of them has a greater inhibitory efficacy compared with inhibition of either factor alone. It was designed for the treatment of cancer, or inflammatory diseases, autoimmune diseases, rheumatoid arthritis, psoratic arthritis, muscle diseases, multiple sclerosis, chronic kidney diseases, bone diseases, systemic lupus erythematosus, lupus nephritis and vascular injury.
Specific Inquiry
Specifications
- Target
- Tweak & IL17
- Type
- CrossMab
- Species Reactivity
- Human
- Target 1
- Tweak
- Host Species 1
- Rabbit
- Target 2
- IL17
- Host Species 2
- Mouse
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- cancer, or Inflammatory diseases, Autoimmune diseases, Rheumatoid arthritis, Psoratic arthritis, Muscle diseases, Multiple sclerosis, Chronic kidney diseases, Bone diseases, Systemic lupus erythematosus, Lupus nephritis and Vascular injury.
Target
- Target 1
- Tweak
- Gene ID
- 8742
- UniProt ID
- O43508
- Alternative Names
- TNFSF12; tumor necrosis factor (ligand) superfamily, member 12; APO3L; DR3LG; TWEAK; tumor necrosis factor ligand superfamily member 12; APO3 ligand; APO3/DR3 ligand; TNF-related WEAK inducer of apoptosis
- Target 2
- IL17
- Gene ID
- 3605
- UniProt ID
- Q16552
- Alternative Names
- IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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