Recombinant Anti-VEGF × Anti-HER2 Bispecific Antibody (Tandem Diabody)
CAT#: TAND-L013
Recombinant Anti-VEGF × Anti-HER2 Bispecific Antibody (Tandem Diabody) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. Tandem Diabodies do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than tandem scFvs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with tandem scFvs. It was designed for the treatment of colorectal tumor, breast cancer, lung cancer, renal cell carcinoma, glioma, glioblastoma and ovarian cancer.
Specifications
- Target
- VEGF & HER2
- Type
- Tandem Diabody
- Species Reactivity
- Human
- Target 1
- VEGF
- Host Species 1
- Human
- Target 2
- HER2
- Host Species 2
- Mouse
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Colorectal tumor, Breast cancer, Lung cancer, Renal cell carcinoma, Glioma, Glioblastoma, Ovarian cancer
Target
- Target 1
- VEGF
- Gene ID
- 7422
- UniProt ID
- P15692
- Alternative Names
- VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor
- Target 2
- HER2
- Gene ID
- 2064
- UniProt ID
- P04626
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
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