EETI-II scaffold protein anti-Bovine Bovine pancreas chymotrypsin (BPC) (CAT#: SEE-L084)
The EETI-II that bound Bovine pancreas chymotrypsin (BPC) was isolated from the library using mRNA display techonology. After affinity maturation, EETI-II variants were identified having affinities (KD=5.5 pM) for Bovine pancreas chymotrypsin (BPC) as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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Normal Tissue
Figure 1 High expression in pancreas
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46920/108848_A_2_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46920/108848_A_2_3_val_selected.jpg
Figure 2 Low expression in colon
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46920/108848_A_8_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46920/108848_A_8_3_val_selected.jpg
Figure 3 Pancreas
(Exocrine glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46920/108848_A_2_3.jpg
(Exocrine glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46920/108848_A_2_3.jpg
Specifications
- Scaffold Name
- EETI-II
- Origin
- Trypsin-specific squash inhibitor EETI II
- Core Structure
- Coiled, cys-rich (28)
- Variable Regions
- 6 aa
- Target
- Bovine pancreas chymotrypsin (BPC)
- Species Reactivity
- Bovine
- Expression Host
- E. coli
- Affinity Constant
- 5.5 pM
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
- Alternative Names
- trypsin-specific squash inhibitor EETI II; EETI-II; bPTLP
- Gene ID
- 514047
- UniProt ID
- Q7M3E1
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