H-2Db/Mycobacterium tuberculosis ESAT-6 (AIQGNVTSI) MHC Tetramer
CAT#: MHC-LC766
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of M. bovis-derived peptide of AIQGNVTSI sequence covering 17-25 and H-2Db molecule. The pMHC tetramer recognizes mouse CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specifications
- Allele
- H-2Db
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- Mycobacterium tuberculosis ESAT-6
- Antigen Species
- M. bovis
- Peptide
- AIQGNVTSI
- Range
- 17-25
- Application
- FCM
Target
- Antigen Introduction
- Mycobacterium bovis (M. bovis) is a slow-growing (16- to 20-hour generation time) aerobic bacterium and the causative agent of tuberculosis in cattle (known as bovine TB). It is related to Mycobacterium tuberculosis—the bacterium which causes tuberculosis in humans—M. bovis, and can jump the species barrier and cause tuberculosis in humans and other mammals.
- Alternative Names
- M. bovis ESAT-6; Mycobacterium bovis ESAT-6 like protein 6; esxO
- Gene ID
- 1094363
- UniProt ID
- A0A0H3P4F6
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Effective ESAT-6 Specific Tool
This H-2Db tetramer loaded with the M. bovis ESAT-6 peptide AIQGNVTSI was vital for our tuberculosis research. We detected specific CD8 T cells in our mouse models. The reagent provided clear staining that helped us track the immune response.
Reliable Mycobacterial Antigen Reagent
We used this product to analyze T cell immunity to the ESAT-6 protein. The tetramer's specificity for the target epitope was high, enabling us to generate robust data on the cellular response to Mycobacterium infection.
Q&As
-
What organism is M. bovis related to?
A: Mycobacterium bovis (M. bovis) is closely related to Mycobacterium tuberculosis, the causative agent of human tuberculosis. M. bovis causes tuberculosis in cattle but can also infect humans and other mammals.
-
What is the peptide sequence in this H-2Db tetramer?
A: The peptide sequence is AIQGNVTSI, which corresponds to residues 17-25 of the ESAT-6 protein (Early Secretory Antigen Target-6) from M. bovis. It is a key target for the immune response.
View the frequently asked questions answered by Creative Biolabs Support.
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See other products for "M. bovis ESAT-6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC573 | I-Ab/Mycobacterium tuberculosis ESAT-6 (MTEQQWNFAGIEAAASAIQG) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC600 | PE-A*02:01/Mycobacterium tuberculosis ESAT-6 (AMASTEGNV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC601 | APC-A*02:01/Mycobacterium tuberculosis ESAT-6 (AMASTEGNV) MHC Tetramer | FCM |
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