H-2Kd/L. monocytogenes LLO (GYKDGNEYI) MHC Tetramer (CAT#: MHC-LC762)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of L. monocytogenes-derived peptide of GYKDGNEYI sequence covering 91-99 and H-2Kd molecule. The pMHC tetramer recognizes mouse CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

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Custom Production

MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

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Antigen Molecule:
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Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

We require custom production
  • Datasheet
  • MSDS
  • COA

Specifications

  • Allele
  • H-2Kd
  • Class
  • Class I
  • MHC Species
  • Mouse
  • Antigen
  • L. monocytogenes LLO
  • Antigen Species
  • L. monocytogenes
  • Peptide
  • GYKDGNEYI
  • Range
  • 91-99
  • Application
  • FCM

Target

  • Antigen Introduction
  • Listeria monocytogenes is the species of pathogenic bacteria that causes the infection listeriosis. It is a facultative anaerobic bacterium, capable of surviving in the presence or absence of oxygen. It can grow and reproduce inside the host's cells and is one of the most virulent foodborne pathogens, with 20 to 30% of food borne listeriosis infections in high-risk individuals may be fatal.Responsible for an estimated 1,600 illnesses and 260 deaths in the United States annually, listeriosis ranks third in total number of deaths among food borne bacterial pathogens, with fatality rates exceeding even Salmonella and Clostridium botulinum. In the European Union listeriosis follows an upward trend that began in 2008, causing 2,161 confirmed cases and 210 reported deaths in 2014, 16% more than in 2013. Listeriosis mortality rates are also in the EU higher than for other food-borne pathogens.
  • Alternative Names
  • L. monocytogenes LLO; Listeria monocytogenes listeriolysin O; hly

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User-Friendly Protocols
The tetramer integrates easily into our standard flow cytometry protocols. The provided instructions are clear, and even new lab members have no trouble using it. It's made our workflow more efficient and productive.

Cost-Effective Solution
Considering its quality and impact on our research, this tetramer is a cost-effective addition to our laboratory. It has streamlined our experiments and reduced the need for additional reagents, ultimately saving us time and resources.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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