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Anti-CD180 (clone MHR73-11)-SPP-DM1 ADC (CAT#: ADC-197LZY)

This ADC product is composed of an anti-CD180 antibody (clone MHR73-11) conjugated via SPP linker to DM1 (MHR73-11-SPP-DM1). It has demonstrated a response in non-Hodgkin's lymphoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3740/2014_H4_2_selected.jpg
Normal Tissue
Figure 2 Tonsil
Figure 2 Tonsil
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3740/11073_A_4_8_val_selected.jpg
Figure 3 Colon
Figure 3 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3740/11073_A_9_3.jpg
Figure 4 Kidney
Figure 4 Kidney
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3740/11073_A_7_5.jpg
Figure 5 Lymph node
Figure 5 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3740/11073_A_8_8.jpg
Figure 6 Spleen
Figure 6 Spleen
(Cells in red pulp Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in white pulp Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3740/11073_B_8_4.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (Daudi, Karpas-707, U-266/70, U-266/84, U-698)
Figure 7 RNA cell line category: Group enriched (Daudi, Karpas-707, U-266/70, U-266/84, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134061-CD180

Specifications

  • Antibody Overview
  • Mouse Anti-CD180 IgG1,MHR73-11
  • Clone
  • MHR73-11
  • Antibody Isotype
  • IgG1
  • Linker
  • SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)
  • Linker Class/Description
  • Class: Chemically cleavable Linker-Disulfide Linker
    Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
  • Drug
  • DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

Target

  • Introduction
  • CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • CD180; CD180 molecule; LY64; Ly78; RP105; CD180 antigen; lymphocyte antigen 64; radioprotective 105 kDa protein; lymphocyte antigen-64, radioprotective, 105kDa;

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Recombinant Antibody

CAT Product Name Application Type
MOB-3084z Mouse Anti-CD180 Recombinant Antibody (clone 43B1) FC IP, FuncS Mouse IgG1, κ
MOB-1053CT Mouse Anti-CD180 Recombinant Antibody (clone H39-9) FC, FuncS, IP Mouse IgG1
FN-144CQ Rat Anti-CD180 Recombinant Antibody (clone RP/14) FC, FuncS Rat IgG2a, κ
VS3-FY251 Recombinant Mouse Anti-CD180 Antibody (clone 1B3C4) ELISA, IHC, ICC, FC Mouse IgG1
VS3-FY252 Recombinant Mouse Anti-CD180 Antibody (clone 2A4D6) ELISA, IHC, FC Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0537 Hi-Affi™ Rabbit Anti-CD180 Recombinant Antibody (clone DS537AB) IHC-P, WB Rabbit IgG

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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