Anti-CD180 (clone MHR73-11)-SPP-DM1 ADC (CAT#: ADC-197LZY)

• Antibody Overview
• Mouse Anti-CD180 IgG1,MHR73-11

• Clone
• MHR73-11

• Antibody Isotype
• IgG1

• Linker
• SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)

• Linker Class/Description
• Class: Chemically cleavable Linker-Disulfide Linker
  Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.

• Drug
• DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)

• Drug Class/Description
• Class: Maytansinoid
  Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

• Introduction
• CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]

• Alternative Names
• CD180; CD180 molecule; LY64; Ly78; RP105; CD180 antigen; lymphocyte antigen 64; radioprotective 105 kDa protein; lymphocyte antigen-64, radioprotective, 105kDa;

• Gene ID
• 4064

• UniProt ID
• Q99467

• ADC-198LZY
• Anti-CD180 (clone MHR73-11)-MCC-DM1 ADC

• ADC-199LZY
• Anti-CD180 (clone MHR73-11)-mc-vc-PABC-MMAE ADC

• ADC-200LZY
• Anti-CD180 (clone MHR73-11)-mc-MMAF ADC

• FN-236CQ
• Mouse Anti-CD180 Recombinant Antibody (clone MHR73-11)

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