MTI-II scaffold protein anti-Human Chymotrypsin (CAT#: SMT-L143)
The MTI-II that bound Chymotrypsin was isolated from the library using Phage display techonology. After affinity maturation, MTI-II variants were identified having affinities (KD=60 nM) for Chymotrypsin as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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Normal Tissue
Figure 1 High expression in pancreas
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46920/108848_A_2_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46920/108848_A_2_3_val_selected.jpg
Figure 2 Low expression in colon
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46920/108848_A_8_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46920/108848_A_8_3_val_selected.jpg
Figure 3 Pancreas
(Exocrine glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46920/108848_A_2_3.jpg
(Exocrine glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46920/108848_A_2_3.jpg
Specifications
- Scaffold Name
- MTI-II
- Origin
- Mustard trypsin inhibitor MTI-2
- Core Structure
- α/βe (63)
- Variable Regions
- 5 aa
- Target
- Chymotrypsin
- Species Reactivity
- Human
- Expression Host
- E. coli
- Affinity Constant
- 60 nM
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
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