Monomethyl auristatin F methyl ester
CAT#: ADCsR-203CL
Monomethyl auristatin F is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. It is linked to an antibody with high affinity to structures on cancer cells, causing MMAF to accumulate in such cells. MMAF is a Tubulin inhibitor. Mode of action: prevent tubulin polymerization.
Specifications
- Synonyms
- MMAF-OMe
- Formula
- C40H67N5O8
- Molecular Weight
- 745,99 g/mol
- Purity
- 95%
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Effective Antimitotic Compound
We acquired Monomethyl auristatin F methyl ester for our in-house conjugation development. This antimitotic agent proved to be a powerful inhibitor of cell division in our testing. It effectively blocks the polymerization of tubulin, which is the mechanism we needed to replicate for our comparative toxin studies.
High Quality Research Reagent
The product arrived with the high purity required for our analytical chemistry workflows. We utilized it to study the binding kinetics to the vinca alkaloid binding domain of tubulin. The compound's performance was consistent.
Q&As
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What is the biological activity of Monomethyl auristatin F?
A: Monomethyl auristatin F (MMAF) is an antimitotic agent. It inhibits cell division by blocking the polymerization of tubulin. It binds powerfully to the vinca alkaloid binding domain of tubulin, causing cells to accumulate in metaphase arrest.
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What is the primary mechanism of action for Monomethyl auristatin F methyl ester (MMAF-OMe) in research applications?
A: Monomethyl auristatin F methyl ester (MMAF-OMe) acts as a potent antimitotic agent and tubulin inhibitor. According to the product specifications, it exerts its cytotoxic effect by blocking the polymerization of tubulin, which effectively inhibits cell division. In the context of targeted research, such as Antibody-Drug Conjugate (ADC) development, this payload is designed to accumulate within cancer cells to induce cell cycle arrest and apoptosis.
View the frequently asked questions answered by Creative Biolabs Support.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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