Anti-FcRH5 (clone 6H1)-SMCC-DM1 ADC

Name: Anti-FcRH5 (clone 6H1)-SMCC-DM1 ADC
SKU: ADC-162CL
Rating: 5 (1 reviews)

CAT#: ADC-162CL

This ADC product is composed of an anti-FcRH5 antibody (clone 6H1) conjugated via SMCC linker to DM1(Mu-anti-FcRH5 (6H1)-mcc-dm1). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.

Gene Expression

RNA Expression Figure 1 RNA cell line category: Group enriched (U-266/70, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143297-FCRL5

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Specifications

Antibody Overview
Mu-Anti-FcRH5 (6H1)

Clone
6H1

Linker
SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)

Linker Class/Description
Class: Noncleavable linkers
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

Drug
DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)

Drug Class/Description
Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

Target

Introduction
This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]

Alternative Names
FCRL5; Fc receptor-like 5; CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820; Fc receptor-like protein 5; fcR-like protein 5; fc receptor homolog 5; immune receptor translocation-associated protein 2; immunoglobulin superfamily receptor translocation associated 2 (IRTA2);

Gene ID
83416

UniProt ID
Q96RD9

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Datasheet

Datasheet - ADC-162CL.pdf

MSDS

MSDS - ADC-162CL.pdf

COA

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