PE-B*07:02/Human MHC class I HLA-A (APRTLVLLL) MHC Tetramer
CAT#: MHC-LC4388
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human MHC class I HLA-A of peptide APRTLVLLL covering 2-10 and B*07:02 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specifications
- Allele
- B*07:02
- Class
- Class I
- MHC Species
- Human
- Antigen
- MHC class I HLA-A
- Antigen Species
- Human
- Peptide
- APRTLVLLL
- Range
- 2-10
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
- Alternative Names
- MHC class I HLA-A; MHC class I HLA-A; HLAA
- Gene ID
- 3105
- UniProt ID
- O78126
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