Src homology domain 2 (SH2) anti-phosphotyrosine (SSW-L191)

The Src homology domain 2 (SH2) that bound phosphotyrosine (pY) was isolated from the library using Filter screening techonology. After affinity maturation, SH2 variants were identified having affinities (KD=1 nM) for phosphotyrosine (pY) as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Scaffold Name
Src homology domain 2 (SH2)
PLCgamma C-terminal SH2 domain
Core Structure
α/β (~100)
Variable Regions
5 aa
Phosphotyrosine (pY)
Expression Host
E. coli
Affinity Constant
1 nM
ELISA; IHC; Microscopy; FC; WB; FuncS
Alternative Names
PLCgamma C-terminal SH2 domain; Src homology domain 2 (SH2); phosphotyrosine; pY

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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