Tripolin A
CAT#: ADCsR-237CL
Triptolin A is described as an specific non-ATP competitve Aurora A kinase inhibitor. Tripolin A doesn`t significantly inhibit Aurora B kinase in mammalian cells. Tripolin A reduces localization of pAurora A on spindle microtubules, affects centrosome integrity, spindle formation and lenght and MT dynamitcs in interphase. Tripolin A is a novel small molecule inhibitor of aurora A kinase.
Specifications
- Longtext
- [(3E)-3-[(2,5-Dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one]
- Formula
- C15H11NO3
- CAS No.
- 1148118-92-6
- Molecular Weight
- 253,25 g/mol
- Purity
- 95%
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Aurora A Specificity Confirmed
This small molecule inhibitor has shown excellent specificity in our assays. Tripolin A effectively targets Aurora A kinase without significant inhibition of Aurora B in the mammalian cell lines we tested. This distinction is crucial for our research into centrosome integrity and spindle formation dynamics during the interphase.
Impact On Spindle Microtubules
We utilized Tripolin A to investigate its effects on microtubule dynamics and found that it significantly reduces the localization of pAurora A on spindle microtubules. The compound's ability to affect spindle length and formation provided valuable data for our studies on non-ATP competitive kinase inhibition mechanisms.
Q&As
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Does Tripolin A inhibit Aurora B kinase as well as Aurora A?
A: No, Tripolin A is described as a specific non-ATP competitive Aurora A kinase inhibitor. In mammalian cells, it does not significantly inhibit Aurora B kinase. This specificity allows for targeted research into the functions and pathways associated primarily with Aurora A.
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What cellular structures does this inhibitor affect?
A: Tripolin A reduces the localization of pAurora A on spindle microtubules. It affects centrosome integrity, spindle formation, and spindle length. Additionally, it impacts microtubule dynamics during the interphase, making it a useful tool for studying these specific cellular mechanisms.
View the frequently asked questions answered by Creative Biolabs Support.
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