Anti-ENPP3-mc-MMAF ADC
CAT#: ADC-021LZY
This ADC product is composed of an anti-ENPP3 antibody conjugated via mc linker to MMAF (anti-ENPP3-mc-MMAF). It is in phase I clinical trials and has demonstrated a response in renal cell carcinoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Normal Tissue
Figure 1 High expression in seminal vesicle
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43772/99239_A_8_6_val_selected.jpg
Normal Tissue
Figure 2 Low expression in placenta
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43772/99239_A_1_7_val_selected.jpg
Normal Tissue
Figure 3 Small intestine
Enterocytes - Microvilli Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43772/99239_A_5_2.jpg
Normal Tissue
Figure 4 Kidney
Proximal tubules (microvilli) Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43772/99239_A_8_5.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (HEL, Hep G2, HMC-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000154269-ENPP3
❮
❯
Specifications
- Antibody Overview
- Fully Human Anti-ENPP3 IgG 2 k
- Antibody Isotype
- IgG 2 k
- Linker
- mc (maleimidocaproyl)
- Linker Class/Description
- Class: Noncleavable linker
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
- Drug
- MMAF (monomethyl auristatin F)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. [provided by RefSeq, Jul 2008]
- Alternative Names
- ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3; B10; NPP3; PDNP3; CD203c; PD-IBETA; ectonucleotide pyrophosphatase/phosphodiesterase family member 3; gp130RB13-6; phosphodiesterase-I beta; phosphodiesterase I/nucleotide pyrophosphatase 3; dJ914N13.3 (phosphodiesterase I/nucleotide pyrophosphatase 3); dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3);
- Gene ID
- 5169
- UniProt ID
- O14638
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for ADC-021LZY. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "ENPP3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2302z | Mouse Anti-ENPP3 Recombinant Antibody (clone 5C1) | WB, ELISA, IP | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0665CT | Recombinant Mouse anti-Human ENPP3 Monoclonal antibody (OQ5E7) | FC, ICC, IF |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS4-WK160 | Human Anti-ENPP3 Recombinant Antibody (clone 3B2) | ELISA, FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0723-WK17 | Human Anti-ENPP3 Recombinant Antibody (clone Xencor) | FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC375 | SmartAb™ Recombinant Anti-ENPP3 pH-dependent Antibody (VS-0825-YC375) | FC | Human IgG1 |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, IHC
Application: WB, IP, IF, FuncS, FC, Neut, ELISA
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
-2-1.png)
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, Neut, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
