Anti-FLAG-SPDP-NCS ADC
CAT#: ADC-153LZY
This ADC product is composed of an anti-FLAG antibody conjugated via SPDP linker to NCS (anti-FLAG IgG-SPDP-NCS). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of inhibiting DNA synthesis .
Specifications
- Antibody Overview
- Anti-FLAG IgG
- Antibody Isotype
- IgG
- Linker
- SPDP(N-succinimidyl 3-[2-pyridyldithio]-propionate)
- Linker Class/Description
- Class: Chemically cleavable Linker-Disulfide Linker
Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- NCS
- Drug Class/Description
- Class: Neocarzinostatin
Description: Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus. It is a product naturally found as a complex of an enediyne chromophore and a 10-kDa protein and it can induce both single-and double-strand breaks in DNA.
Target
- Alternative Names
- flaG; flagellar protein FlaG
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COA
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