Recombinant Human Anti-Avian influenza virus Antibody (65C6) (CAT#: HPAB-0508-WJ)

Figure 1 Western blot analysis of binding specificities of antibodies 65C6, 3C11, and 100F4.

TG15 is a control antibody that recognizes an epitope in the HP2 domain of HIV-1 gp41.

Hu, H., Voss, J., Zhang, G., Buchy, P., Zuo, T., Wang, L., ... & Calder, L. (2012). A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses. Journal of virology, 86(6), 2978-2989.

Figure 2 Therapeutic efficacy of antibody 65C6 in mice.

Survival rate of each group infected with HPAI H5N1 A/Shenzhen/406H/06 virus and treated with 40 mg/kg of antibody 65C6 at 24, 48, and 72 h postinfection.

Hu, H., Voss, J., Zhang, G., Buchy, P., Zuo, T., Wang, L., ... & Calder, L. (2012). A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses. Journal of virology, 86(6), 2978-2989.

Figure 3 Neutralization activity of 65C6 monoclonal antibody against H5N1 SZ06 and H5N8 NE14 pseudotypes using PN assay.

The titration of neutralization activity of antibodies 65C6 against H5N1 SZ06 (green color line) and H5N8 NE14 (red color line) pseudotypes, respectively.

Ren, H., Wang, G., Wang, S., Chen, H., Chen, Z., Hu, H., ... & Zhou, P. (2016, August). Cross-protection of newly emerging HPAI H5 viruses by neutralizing human monoclonal antibodies: a viable alternative to oseltamivir. In MAbs (Vol. 8, No. 6, pp. 1156-1166). Taylor & Francis.

Figure 4 Antibodies 65C6 and irrelevant IgG1 antibody were immobilized on a CM5 sensor chip for surface plasmon resonance (SPR) kinetic binding analysis with the H5 HA proteins.

Hu, H., Voss, J., Zhang, G., Buchy, P., Zuo, T., Wang, L., ... & Calder, L. (2012). A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses. Journal of virology, 86(6), 2978-2989.