Anti-CD109 (clone W24W7C5) Recombinant Antibody Coupled Liposome (VS-1024-FY261)
CAT#: VS-1024-FY261
The Anti-CD109 Antibody Liposome is engineered to effectively encapsulate and transport therapeutic agents directly to cells that express the CD109 glycoprotein, which is commonly found in several types of cancers and stem cells. By honing in on these specific cellular targets, this innovative drug delivery system seeks to significantly boost treatment effectiveness and reduce unwanted side effects, ultimately transforming the therapeutic landscape for patients.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line ASC TERT1
Immunofluorescent staining of human cell line ASC TERT1 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8992/1876_G4_26_cr5b7167eac2cf3_selected.jpg
Normal Tissue
Figure 2 High expression in parathyroid gland
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15723/164976_A_2_8_val_selected.jpg
Normal Tissue
Figure 3 Low expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15723/164976_A_9_4_val_selected.jpg
Normal Tissue
Figure 4 Parathyroid gland
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15723/164976_A_2_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000156535-CD109
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More Infomation
Specifications
- Potential Clinical Applications
- It provides new possibilities for future stem cell research and clinical applications.
Product Composition
- Clone
- W24W7C5
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- The mouse monoclonal antibody W24W7C5 specifically targets CD109, a glycosylphosphatidylinositol (GPI)-anchored extracellular protein with an approximate molecular weight of 165 kDa. This protein is predominantly expressed on various hematopoietic cells, activated T lymphoblasts, activated platelets, and endothelial cells.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CD109
- Introduction
- CD109 is a GPI-linked cell surface antigen expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells, and activated platelets (Lin et al., 2002).
- Alternative Names
- CD109, CPAMD7, p180, r150, CD109 molecule
- Full Name
- Cluster of Differentiation 109
- Gene ID
- 135228
- UniProt ID
- Q6YHK3
- Sequence Similarities
- Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- N-glycosylated. ( Q6YHK3-CD109_HUMAN )
2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form. ( Q6YHK3-CD109_HUMAN )
Glycosylation at Asn41, Asn68, Asn118, Asn247, Asn279, Asn287, Asn337, Asn365, Asn419, Asn513, Asn645, Asn1086, and Asn1355 ( NX_Q6YHK3 [NX_Q6YHK3-1] )
Modification sites at PhosphoSitePlus
- Protein Refseq
- XP_047274167.1; XP_047274168.1; XP_047274169.1; XP_047274170.1; XP_047274171.1
- Function
- Modulates negatively TGFB1 signaling in keratinocytes.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "CD109"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1988z | Mouse Anti-CD109 Recombinant Antibody (clone 27A2) | WB, ELISA, FC | Mouse IgG1 |
| MOB-0374CT | Mouse Anti-CD109 Recombinant Antibody (clone C-F58) | FC | Mouse IgG1 |
| VS3-FY234 | Recombinant Mouse Anti-CD109 Antibody (clone 1A3D3) | ELISA, ICC, FC | Mouse IgG1 |
| VS3-FY235 | Recombinant Mouse Anti-CD109 Antibody (clone 3B5G6) | ELISA, IHC, ICC, FC | Mouse IgG1 |
| VS7-HM341 | Mouse Anti-CD109 Recombinant Antibody (clone 5E11A12) | FCM | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1115 | Anti-CD109 Immunohistochemistry Kit | IHC |
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