DrugMonitor™ Rabbit Anti-Chlorotoxin Antibody (VS-0125-YC562)
CAT#: VS-0125-YC562
Chlorotoxin I-131, in trials for brain cancer, diminishes matrix metalloproteinase activity impacting chloride channels. This product is the DrugMonitor™ Anti-Chlorotoxin Antibody (VS-0125-YC562), specifically designed as an anti-drug antibody (ADA) that targets Chlorotoxin. The ADA was raised in rabbits immunized with Chlorotoxin conjugated to BSA and is suitable for use in ELISA and lateral flow assays. This antibody may be employed in pharmacokinetics (PK) and pharmacodynamics (PD) analyses, or as a reference standard in ADA assays. Furthermore, as a drug-based antibody, it serves as an exemplary tool for therapeutic drug monitoring, facilitating the determination of Chlorotoxin drug concentrations in various samples.
Specifications
- Host Animal
- Rabbit
- Specificity
- Chlorotoxin
- Target
- Chlorotoxin
- Immunogen
- Chlorotoxin conjugated to BSA
- Type
- Rabbit IgG
- Purity
- >95%
- Purification
- Protein G purified
- Conjugate
- Unconjugated
- Applications
- ELISA, Lateral Flow, PK/PD, ADA Control
- Format
- BSA and Azide Free. This formulation is ideal for antibody labeling (e.g. fluorophores, enzymes, small drugs, and oligonucleotides) and functional assays (e.g. In vitro and In vivo).
- Buffer
- PBS, pH 7.2
- Preservative
- No preservatives
- Storage
- Store at 4°C for 1-2 weeks and at -20°C for 1 year. Avoid repeated freezing and thawing.
- Drug Weight
- 373.5304 Da
- Formula
- C₂₆H₃₁NO
- Related Disease
- Brain cancer
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Excellent For Labeling And Assays
The formulation of this rabbit antibody is ideal for our needs since it lacks BSA and preservatives. We conjugated it with a fluorophore for direct detection of Chlorotoxin in brain cancer research models, and the signal-to-noise ratio was excellent.
Reliable Chloride Channel Research Tool
Investigating the impact of Chlorotoxin on matrix metalloproteinase activity requires precise tools. This antibody allowed us to confirm the presence of the peptide in our system, supporting our pharmacodynamic studies on its mechanism of action in tumor environments.
Q&As
-
What is the biological function of the target Chlorotoxin?
A: Chlorotoxin is known to diminish matrix metalloproteinase activity, which impacts chloride channels. It has been investigated in trials for brain cancer. Our antibody specifically targets Chlorotoxin to assist in researching these mechanisms and monitoring the drug.
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Why is the formulation of this antibody beneficial for labeling?
A: This antibody is supplied in a buffer that is free of BSA and Azide. This formulation is ideal for antibody labeling with fluorophores, enzymes, small drugs, and oligonucleotides, as there are no carrier proteins or preservatives to interfere with the conjugation process.
View the frequently asked questions answered by Creative Biolabs Support.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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