Anti-CLEC4C (clone W24V8) Recombinant Antibody Coupled Liposome (VS-1024-FY9)
CAT#: VS-1024-FY9
Anti-CLEC4C antibody-conjugated liposomes represent a groundbreaking advancement in targeted drug delivery systems, demonstrating significant potential in the treatment of cancer and other pathological conditions. By leveraging the specificity of antibodies against the CLEC4C receptor-an important marker often overexpressed on the surface of certain cancer cells-these engineered liposomes can effectively localize and interact with malignant tissues. The use of liposomes as a drug delivery vehicle offers additional benefits, including the ability to encapsulate a wide variety of therapeutic agents, from small molecules to larger biologics. This versatility, combined with targeted delivery, signifies a promising evolution in therapeutic strategies, paving the way for tailored treatments that are more effective and have fewer adverse effects. Overall, anti-CLEC4C antibody-conjugated liposomes exemplify a significant leap forward in the quest for more precise and efficient cancer therapies, presenting a potent tool for both researchers and clinicians in the ongoing battle against malignancies.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29432/60664_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29432/60664_A_9_3.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29432/60664_A_7_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29432/60664_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29432/60664_A_6_6.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29432/60664_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000198178-CLEC4C
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More Infomation
Specifications
- Potential Clinical Applications
- Specific targeting of dendritic cells
Product Composition
- Clone
- W24V8
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- CLEC4C BIIB059 is a therapeutic antibody targeting CLEC4C (C-type lectin domain family 4 member C). This drug is primarily used for treating certain types of cancer, particularly tumors associated with immune modulation. By targeting CLEC4C, this antibody may enhance the immune system's ability to recognize and attack tumor cells.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CLEC4C
- Introduction
- This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene.
- Alternative Names
- C-Type Lectin Domain Family 4 Member C; C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 7; C-Type Lectin Domain Family 4, Member C; C-Type Lectin Superfamily Member 7; Dendritic Lectin; CLECSF11; CLECSF7; BDCA-2; BDCA2; DLEC
- Full Name
- C-Type Lectin Domain Family 4 Member C
- Gene ID
- 170482
- UniProt ID
- Q8WTT0
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn110, Asn137, and Asn164
Glycosylation from GlyGen 3 sites
- Protein Refseq
- XP_024304641.1; XP_054227312.1; XP_054227313.1; XP_054227314.1; NP_001358319.1
- Function
- Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, 21880719, 25995448).
Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, 25995448).
Binds to serum IgG.
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-217-F(E) | Recombinant Anti-human CLEC4C Antibody Fab Fragment | IP, Neut, FuncS | Fab |
| MHH-217-F(E) | Recombinant Human Anti-human CLEC4C Antibody Fab Fragment | ELISA, WB, IF, FuncS | Fab |
| HPAB-1285LY-F(E) | Human Anti-CLEC4C Recombinant Antibody; Fab Fragment (HPAB-1285LY-F(E)) | ELISA | Human Fab |
| HPAB-1286LY-F(E) | Human Anti-CLEC4C Recombinant Antibody; Fab Fragment (HPAB-1286LY-F(E)) | ELISA | Human Fab |
| HPAB-1287LY-F(E) | Human Anti-CLEC4C Recombinant Antibody; Fab Fragment (HPAB-1287LY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-217 | Recombinant Human Anti-human CLEC4C Antibody | Neut, IF, FuncS | IgG |
| HPAB-1285LY | Human Anti-CLEC4C Recombinant Antibody (HPAB-1285LY) | ELISA | Human IgG |
| VS-0723-WK15 | Human Anti-CLEC4C Recombinant Antibody (clone Litifilimab) | ELISA, FC | Human IgG1 |
| VS3-FY2670 | Mouse Anti-CLEC4C Recombinant Antibody (VS3-FY2670) | FC, ELISA | Mouse IgG |
| VS13-YC226 | Rabbit Anti-CLEC4C Recombinant Antibody (VS13-YC226) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0425CL | Mouse Anti-CLEC4C Recombinant Antibody (TAB-0425CL) | IF | Mouse IgG |
| TAB-0425CL-S(P) | Mouse Anti-CLEC4C Recombinant Antibody; scFv Fragment (TAB-0425CL-S(P)) | ELISA, IF, FuncS | Mouse scFv |
| TAB-1244CL-S(P) | Mouse Anti-CLEC4C Recombinant Antibody; scFv Fragment (TAB-1244CL-S(P)) | ELISA | Mouse scFv |
| TAB-0425CL-F(E) | Mouse Anti-CLEC4C Recombinant Antibody; Fab Fragment (TAB-0425CL-F(E)) | ELISA, IF, FuncS | Mouse Fab |
| TAB-1244CL-F(E) | Mouse Anti-CLEC4C Recombinant Antibody; Fab Fragment (TAB-1244CL-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0461CL | Human Anti-CLEC4C Recombinant Antibody (TAB-0461CL) | ELISA | Human IgG |
| TAB-0462CL | Human Anti-CLEC4C Recombinant Antibody (TAB-0462CL) | ELISA | Human IgG |
| TAB-0463CL | Human Anti-CLEC4C Recombinant Antibody (TAB-0463CL) | ELISA | Human IgG |
| TAB-0461CL-S(P) | Human Anti-CLEC4C Recombinant Antibody; scFv Fragment (TAB-0461CL-S(P)) | ELISA | Human scFv |
| TAB-0462CL-S(P) | Human Anti-CLEC4C Recombinant Antibody; scFv Fragment (TAB-0462CL-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1245CL | Human Anti-CLEC4C Recombinant Antibody (TAB-1245CL) | ELISA, Cyt | Chimeric (mouse/human) IgG |
| TAB-1245CL-S(P) | Mouse Anti-CLEC4C Recombinant Antibody; scFv Fragment (TAB-1245CL-S(P)) | ELISA | Mouse scFv |
| TAB-1245CL-F(E) | Human Anti-CLEC4C Recombinant Antibody; Fab Fragment (TAB-1245CL-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1285LY-S(P) | Human Anti-CLEC4C Recombinant Antibody; scFv Fragment (HPAB-1285LY-S(P)) | ELISA | Human scFv |
| HPAB-1286LY-S(P) | Human Anti-CLEC4C Recombinant Antibody; scFv Fragment (HPAB-1286LY-S(P)) | ELISA | Human scFv |
| HPAB-1287LY-S(P) | Human Anti-CLEC4C Recombinant Antibody; scFv Fragment (HPAB-1287LY-S(P)) | ELISA | Human scFv |
| HPAB-1288LY-S(P) | Human Anti-CLEC4C Recombinant Antibody; scFv Fragment (HPAB-1288LY-S(P)) | ELISA | Human scFv |
| HPAB-1289LY-S(P) | Human Anti-CLEC4C Recombinant Antibody; scFv Fragment (HPAB-1289LY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC27 | Recombinant Anti-CLEC4C Vesicular Antibody, EV Displayed (VS-0425-YC27) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1498 | Anti-CLEC4C Immunohistochemistry Kit | IHC |
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