Rabbit Anti-Staphylococcus aureus esxA Antibody (VS-0925-XY58)
CAT#: VS-0925-XY58
Staphylococcus aureus esxA antibodies target this secreted toxin, supporting Western blotting, immunofluorescence in infected cells, and studies on its role in phagosome escape. Critical for researching Staphylococcus aureus intracellular survival and sepsis pathogenesis.
Specifications
- Host Animal
- Rabbit
- Applications
- WB
- Specificity
- Staphylococcus aureus esxA
- Target
- Staphylococcus aureus esxA
- Species Reactivity
- Bacteria
- Type
- Rabbit IgG
- Purification
- Protein G Purified
- Format
- Liquid
- Buffer
- PBS, pH 7.4, with 50% glycerol
- Preservative
- 0.03% ProClin 300
- Storage
- This item should be kept at 4°C if stored for a short period (1 to 2 weeks). For extended storage, maintain a temperature of -20°C. Repeated freeze-thaw cycles must be avoided.
Target
- Introduction
- Staphylococcus aureus esxA is a secreted virulence protein of Staphylococcus aureus, belonging to the ESAT-6/CFP-10 protein family. It is transported out of the bacterium via the Type VII secretion system, a key pathway for delivering virulence factors. EsxA plays critical roles in bacterial pathogenesis: it disrupts the membranes of host phagocytes (like macrophages), allowing Staphylococcus aureus to escape from phagosomes-vesicles that trap and attempt to kill the bacterium. This escape enables the bacterium to replicate freely in host cell cytoplasm. Additionally, esxA modulates host immune responses by suppressing the activation of immune cells and reducing pro-inflammatory cytokine production, creating a favorable environment for bacterial survival. Its conservation across most virulent Staphylococcus aureus strains and essential role in invasive infections make it a promising target for vaccines and novel antibacterial drugs; inhibiting esxA could block phagosome escape and restore host immune clearance.
- Alternative Names
- S. aureus ESAT-6-like Protein A, Sa esxA
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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