Anti-EPHA7 Antibody Prodrug, Protease Activated (VS-1025-YC87)
CAT#: VS-1025-YC87
The Anti-EPHA7 Antibody Prodrug, Protease Activated (VS-1025-YC87) is an antibody prodrug comprised of a recombinant human antibody targeting human EPHA7, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to EPHA7 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to EPHA7 effectively. EPHA7 (Ephrin Receptor A7) is a receptor tyrosine kinase that can function as a tumor suppressor due to its ability to induce apoptosis (cell death) when activated. While its role is context-dependent, its expression is often lost in aggressive cancers, and the methylation of its gene promoter is frequently observed in gastric and colorectal tumors.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10496/32140_B_7_5.jpg
Normal Tissue
Figure 2 Parathyroid gland
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10496/32140_A_3_8.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10496/32140_A_7_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10496/32140_A_9_5.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (AF22, HEK93, RH-30, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000135333-EPHA7
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human EPHA7
- Target
- EPHA7
- Species Reactivity
- Human
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This is an antibody againsts EPHA7, it can be used to treat and diagnose cancer.
- Alternative Names
- EPHA7; EPH receptor A7; EHK3; EK11; EHK-3; HEK11; ephrin type-A receptor 7; EPH-like kinase 11; EPH homology kinase 3; Eph homology kinase-3; receptor protein-tyrosine kinase HEK11; tyrosine-protein kinase receptor EHK-3
- Gene ID
- 2045
- UniProt ID
- Q15375
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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