Anti-ETV1 Antibody Prodrug, Protease Activated (VS-1025-YC67)
CAT#: VS-1025-YC67
The Anti-ETV1 Antibody Prodrug, Protease Activated (VS-1025-YC67) is an antibody prodrug comprised of a recombinant mouse antibody targeting human ETV1, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to ETV1 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to ETV1 effectively. ETV1 is a transcription factor and member of the ETS family, similar to ERG, that becomes an oncogenic driver through gene fusions in various cancers, including prostate cancer (often fused with TMPRSS2). Like ERG, the fusion leads to the overexpression of ETV1, promoting malignant cell growth and survival.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/77249/1623_B11_4_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (AN3-CA, hTERT-RPE1, SCLC-21H, U-87 MG, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000006468-ETV1
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Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human ETV1
- Target
- ETV1
- Species Reactivity
- Human
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Affinity purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "ETV1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4076z | Mouse Anti-ETV1 Recombinant Antibody (MOB-4076z) | WB, IF, ICC, ELISA | Mouse IgG1 |
| MOB-0687CT | Recombinant Mouse anti-Human ETV1 Monoclonal antibody (2D9C7) | ELISA, WB | |
| ZG-0310J | Mouse Anti-ETV1 Recombinant Antibody (ZG-0310J) | WB, ELISA | Mouse IgG |
| VS3-XY655 | Mouse Anti-ETV1 Recombinant Antibody (clone 1C8) | ELISA, WB | Mouse IgG1 |
| VS7-HM915 | Mouse Anti-ETV1 Recombinant Antibody (clone CBL265HM) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4076z-F(E) | Recombinant Anti-Human ETV1 Antibody Fab Fragment | FC, IP, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4076z-S(P) | Recombinant Anti-Human ETV1 Antibody scFv Fragment | WB, IF, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-014WM | Anti-Human ETV1 Recombinant Antibody (2F11G11D10B4) | WB, IF, ELISA | |
| TAB-014WM-S(P) | Anti-Human ETV1 Recombinant Antibody scFv Fragment (2F11G11D10B4) | WB, IF, ELISA | |
| TAB-014WM-F(E) | Anti-Human ETV1 Recombinant Antibody Fab Fragment (2F11G11D10B4) | WB, IF, ELISA |
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