Anti-EZR Antibody Prodrug, Protease Activated (SAIC-37C-23)
CAT#: VS-1025-YC163
The Anti-EZR Antibody Prodrug, Protease Activated (SAIC-37C-23) is an antibody prodrug comprised of a recombinant mouse antibody targeting human EZR, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to EZR protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to EZR effectively. EZR (Ezrin) is a membrane-cytoskeleton linker protein whose overexpression is strongly associated with metastasis and poor prognosis in many cancers, including sarcoma and ovarian cancer. It promotes tumor cell motility, invasion, and resistance to apoptosis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21616/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4035/if_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47324/if_selected.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21616/50443_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21616/50443_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21616/50443_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21616/50443_A_4_6.jpg
Normal Tissue
Figure 8 Placenta
Decidual cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21616/50443_A_1_7.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21616/50443_A_7_8.jpg
RNA Expression
Figure 10 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000092820-EZR
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Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human EZR
- Target
- EZR
- Species Reactivity
- Human
- Isotype
- IgG1
- Clone
- SAIC-37C-23
- Epitope
- SGYLSSER
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein G purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
- Alternative Names
- Ezrin; Villin 2 (Ezrin); Cytovillin 2; VIL2; P81
- Gene ID
- 7430
- UniProt ID
- P15311
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Datasheet
MSDS
COA
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See other products for "Clone SAIC-37C-23"
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0604CT | Recombinant Mouse anti-Human EZR Monoclonal antibody (CL2384) | ELISA, WB |
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|---|---|---|---|
| MOR-1222 | Hi-Affi™ Rabbit Anti-EZR Recombinant Antibody (clone DS1222AB) | ICC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| MRO-0559-CN | Rabbit Anti-EZR Recombinant Antibody (clone JM10-65) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| FAMAB-1132CQ | Mouse Anti-EZR Recombinant Antibody (clone SAIC-37C-23) | Immuno-MRM, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0724-YC1057 | AbPlus™ Anti-EZR Magnetic Beads (VS-0724-YC1057) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
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| VS-0525-XY2399 | Anti-EZR Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
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