Anti-FGF19 Antibody Prodrug, Protease Activated (VS-1025-YC69)
CAT#: VS-1025-YC69
The Anti-FGF19 Antibody Prodrug, Protease Activated (VS-1025-YC69) is an antibody prodrug comprised of a recombinant mouse antibody targeting human FGF19, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to FGF19 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to FGF19 effectively. FGF19 (Fibroblast Growth Factor 19) is a secreted growth factor whose gene amplification is a major oncogenic driver in a subset of hepatocellular carcinoma (HCC) and cholangiocarcinoma. High levels of FGF19 activate FGFR4 on the cancer cells, leading to massive proliferation and reduced bile acid synthesis.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36082/79529_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36082/79529_A_8_3.jpg
Normal Tissue
Figure 3 Gallbladder
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36082/79529_A_5_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36082/79529_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/36082/79529_A_5_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (CAPAN-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000162344-FGF19
❮
❯
Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human FGF19
- Target
- FGF19
- Species Reactivity
- Human
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
- Alternative Names
- Fibroblast Growth Factor 19; FGF-19
- Gene ID
- 9965
- UniProt ID
- O95750
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-946-VHH | Recombinant Anti-Human FGF19 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-047WM | Mouse Anti-FGF19 Recombinant Antibody (TAB-047WM) | Inhib, ELISA, FuncS, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-047WM-S(P) | Mouse Anti-FGF19 Recombinant Antibody; scFv Fragment (TAB-047WM-S(P)) | ELISA, IP, WB, BL | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-047WM-F(E) | Mouse Anti-FGF19 Recombinant Antibody; Fab Fragment (TAB-047WM-F(E)) | ELISA, IP, WB, BL | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0751MZ | Recombinant Mouse Anti-Human FGF19 Antibody (clone NN0396-5H27) | IHC-P | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-799CQ | Mouse Anti-FGF19 Recombinant Antibody (clone CBL320) | WB, Block | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1292 | Hi-Affi™ Rabbit Anti-FGF19 Recombinant Antibody (clone DS1292AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0068-LSX | Mouse Anti-FGF19 Recombinant Antibody (HPAB-0068-LSX) | ELISA, RIA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0069-LSX | Mouse Anti-FGF19 Recombinant Antibody (HPAB-0069-LSX) | ELISA, RIA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0068-LSX-S(P) | Mouse Anti-FGF19 Recombinant Antibody; scFv Fragment (HPAB-0068-LSX-S(P)) | ELISA, RIA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0069-LSX-S(P) | Mouse Anti-FGF19 Recombinant Antibody; scFv Fragment (HPAB-0069-LSX-S(P)) | ELISA, RIA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0068-LSX-F(E) | Mouse Anti-FGF19 Recombinant Antibody; Fab Fragment (HPAB-0068-LSX-F(E)) | ELISA, RIA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0069-LSX-F(E) | Mouse Anti-FGF19 Recombinant Antibody; Fab Fragment (HPAB-0069-LSX-F(E)) | ELISA, RIA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS4-WK175 | Rabbit Anti-FGF19 Recombinant Antibody (clone 11H3) | ELISA, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2522 | Anti-FGF19 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC115 | Recombinant Anti-FGF19 Eliminating Antibody, pH-Sensitive (VS-0625-YC115) | Antigen-Sweeping In Vivo. | Mouse IgG |
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