DrugMonitor™ Anti-GIF Antibody (VS-1224-YC509) (CAT#: VS-1224-YC509)
Intrinsic factor (IF) is a glycoprotein produced by the stomach's parietal cells, essential for the absorption of vitamin B12 (cobalamin) in the small intestine. It is currently included in the marketed product for treating anemias that respond to oral iron therapy. The DrugMonitor™ Anti-GIF Antibody (VS-1224-YC509) is an anti-drug antibody (ADA) against GIF. This drug-based antibody is raised in mice immunized with the Gastric intrinsic factor. The anti-GIF antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the GIF in samples.
Specific Inquiry
Normal Tissue
Figure 1 Stomach 1
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/39908/87887_A_6_1_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/39908/87887_A_6_1_val_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/39908/87887_B_7_5.jpg
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/39908/87887_B_7_5.jpg
Figure 3 Stomach
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/39908/87887_A_3_1.jpg
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/39908/87887_A_3_1.jpg
Figure 4 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/40774/87847_A_5_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/40774/87847_A_5_6.jpg
Specifications
- Host Animal
- Mouse
- Specificity
- Gastric intrinsic factor
- Target
- GIF
- Immunogen
- Gastric intrinsic factor
- Type
- Mouse IgG
- Purity
- >95%
- Purification
- Protein G
- Applications
- ELISA, PK/PD, ADA control
- Format
- Liquid
- Concentration
- Batch-dependent
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for 1-2 weeks and at -20°C for 1 year. Avoid repeated freezing and thawing.
- Generic name
- Gastric intrinsic factor
- Related Disease
- Anemias
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2114z | Mouse Anti-GIF Recombinant Antibody (clone 38G4) | WB, ELISA, IF, IP | Mouse IgG1, κ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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