Mouse Anti-ILDR2 Recombinant Antibody Hexamer (VS-0924-YC134), CDC Enhanced
CAT#: VS-0924-YC134
The product is a mouse anti-ILDR2 antibody hexamer with enhanced complement-dependent cytotoxicity (CDC) activity. This hexameric IgG1 targets human ILDR2 and contains hexamerization-enhancing mutations that promote hexamer formation, enabling optimal C1q binding and significantly improving CDC.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12815/1864_E3_22_cr5afd7c3eba476_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Neuronal cells Staining: Low Intensity: Weak Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12545/30385_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12545/30385_A_7_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12545/30385_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12545/30385_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (AF22, JURKAT, MOLT-4, U-2 OS, U-251 MG)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000143195-ILDR2
❮
❯
Specifications
- Host Species
- Mouse
- Type
- Antibody hexamer
- Specificity
- Human ILDR2
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- ELISA, FC, CDC
- Conjugate
- None
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Immunoglobulin Like Domain Containing Receptor 2
- Gene ID
- 387597
- UniProt ID
- Q71H61
- Long Name
- Immunoglobulin Like Domain Containing Receptor 2
- Sequence Similarities
- Belongs to the immunoglobulin superfamily. LISCH7 family.
- Cellular Localization
- Endoplasmic reticulum membrane; Single-pass type I membrane protein {ECO:0000250 UniProtKB:B5TVM2}
Cell junction, tight junction {ECO:0000250 UniProtKB:B5TVM2}
- Function
- May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion.
With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (By similarity).
Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694).
In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity).
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0924-YC134. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "ILDR2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-704LC | Mouse Anti-ILDR2 Recombinant Antibody (TAB-704LC) | FC | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-702LC-S(P) | Mouse Anti-ILDR2 Recombinant Antibody; scFv Fragment (TAB-702LC-S(P)) | ELISA, FC, IHC | Mouse scFv |
| TAB-703LC-S(P) | Mouse Anti-ILDR2 Recombinant Antibody; scFv Fragment (TAB-703LC-S(P)) | ELISA, FC, IHC | Mouse scFv |
| TAB-702LC-F(E) | Mouse Anti-ILDR2 Recombinant Antibody; Fab Fragment (TAB-702LC-F(E)) | ELISA, FC, IHC | Mouse Fab |
| TAB-703LC-F(E) | Mouse Anti-ILDR2 Recombinant Antibody; Fab Fragment (TAB-703LC-F(E)) | ELISA, FC, IHC | Mouse Fab |
| TAB-704LC-F(E) | Mouse Anti-ILDR2 Recombinant Antibody; Fab Fragment (TAB-704LC-F(E)) | ELISA, FC, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP125-YC | Mouse Anti-ILDR2 Recombinant Antibody (HPAB-AP125-YC) | ELISA, FC, CDC | Mouse IgM, κ |
| HPAB-AP126-YC | Mouse Anti-ILDR2 Recombinant Antibody (HPAB-AP126-YC) | ELISA, FC | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP125-YC-S(P) | Mouse Anti-ILDR2 Recombinant Antibody; scFv Fragment (HPAB-AP125-YC-S(P)) | ELISA, FC, CDC | Mouse scFv |
| HPAB-AP126-YC-S(P) | Mouse Anti-ILDR2 Recombinant Antibody; scFv Fragment (HPAB-AP126-YC-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP125-YC-F(E) | Mouse Anti-ILDR2 Recombinant Antibody; Fab Fragment (HPAB-AP125-YC-F(E)) | ELISA, FC, CDC | Mouse Fab |
| HPAB-AP126-YC-F(E) | Mouse Anti-ILDR2 Recombinant Antibody; Fab Fragment (HPAB-AP126-YC-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC98 | Recombinant Anti-ILDR2 Vesicular Antibody, EV Displayed (VS-0425-YC98) | ELISA, FC, Cell-uptake |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: Neut, ELISA, WB, SPR, IF, EM
-3.jpg)
Application: IB, FC, ELISA, FuncS
Application: ELISA, Inhib, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
