Mouse Anti-ILDR2 Recombinant Antibody Hexamer (VS-0924-YC134), CDC Enhanced (CAT#: VS-0924-YC134)

• Host Species
• Mouse

• Type
• Antibody hexamer

• Specificity
• Human ILDR2

• Species Reactivity
• Human

• Molecule Class
• ~ 900 kDa

• Applications
• ELISA, FC, CDC

• Conjugate
• None

• Clonality
• Monoclonal

• Purification
• Protein G purified

• Purity
• >95% determined as SDS-PAGE and SEC-HPLC

• Aggregation
• <5%

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

• Alternative Names
• Immunoglobulin Like Domain Containing Receptor 2

• Gene ID
• 387597

• UniProt ID
• Q71H61

• Long Name
• Immunoglobulin Like Domain Containing Receptor 2

• Sequence Similarities
• Belongs to the immunoglobulin superfamily. LISCH7 family.

• Cellular Localization
• Endoplasmic reticulum membrane; Single-pass type I membrane protein {ECO:0000250 UniProtKB:B5TVM2}
  Cell junction, tight junction {ECO:0000250 UniProtKB:B5TVM2}

• Function
• May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion.
  With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (By similarity).
  Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694).
  In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity).

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