Recombinant Anti-N. meningitidis fHbp (Gly121/Lys122 x Arg204) Biparatopic Antibody, Tandem scFv (Clone JAR 5 x Clone JAR 1)
CAT#: VS-0525-YC84
The Recombinant Anti-N. meningitidis fHbp (Gly121/Lys122 x Arg204) Biparatopic Antibody, Tandem scFv (Clone JAR 5 x Clone JAR 1) constitutes a biparatopic antibody (bpAb) that simultaneously engages two distinct N. meningitidis fHbp epitopes. This bpAb's tandem scFv structure derives from the JAR 5 scFv (targeting Gly121 and Lys122 of N. meningitidis fHbp protein) N-terminally fused to the JAR 1 scFv (specific for Arg204 of N. meningitidis fHbp protein).
Specifications
- Host Animal 1
- Mouse
- Host Animal 2
- Mouse
- Specificity
- N. meningitidis fHbp
- Species Reactivity
- N. meningitidis
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- JAR 5
- Clone 2
- JAR 1
- Epitope 1
- Gly121 and Lys122
- Epitope 2
- Arg204
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- Block, ELISA, FC, WB
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Factor H binding protein
Target
- Introduction
- Factor H binding protein (fHbp) that is exhibited in N. meningitidis and some commensal species is the main inhibitor of the alternative complement pathway. fHbp protects meningococci from complement-mediated death in human serum experiments, but has also been shown to protect meningococci from antimicrobial peptides in vitro. Factor H binding protein is key to the pathogenesis of N. meningitidis, and is, therefore, important as a potential vaccine candidate.
- Alternative Names
- fhbP; Factor H-binding protein
- UniProt ID
- C6KHT4
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