Anti-NCOA3 (clone W24V194) Recombinant Antibody Coupled Liposome (VS-1024-FY194)
CAT#: VS-1024-FY194
The liposome conjugated with anti-NCOA3 antibodies provides a new strategy for targeted therapy in melanoma, as NCOA3 is a key factor in regulating tumor cell proliferation. This liposome can effectively recognize and target tumor cells for the delivery of anticancer drugs. By directing the drug to the tumor site, it can enhance therapeutic efficacy and reduce systemic toxicity. Recent research indicates that its targeting characteristics help control cancer progression.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24210/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24210/62188_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24210/62188_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24210/62188_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24210/62188_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24210/62188_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24210/62188_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (MCF7)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000124151-NCOA3
❮
❯
More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- W24V194
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody engineered to specifically bind to nuclear receptor coactivator 3 (NCOA3). NCOA3 is an essential protein that serves as a coactivator for numerous nuclear receptors, playing a significant role in transcriptional regulation and cellular signaling pathways. The ability of this antibody to selectively target NCOA3 allows researchers to study its function in cancer biology and other diseases, potentially paving the way for novel therapeutic strategies that modulate its activity.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- NCOA3
- Introduction
- The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.
- Alternative Names
- Nuclear Receptor Coactivator 3; Thyroid Hormone Receptor Activator Molecule 1; Receptor-Associated Coactivator 3; Class E Basic Helix-Loop-Helix Protein 42; Steroid Receptor Coactivator Protein 3; Amplified In Breast Cancer 1 Protein; CBP-Interacting Protein; EC 2.3.1.48; BHLHe42; TRAM-1; AIB-1; SRC-3; AIB1
- Full Name
- Nuclear Receptor Coactivator 3
- Gene ID
- 8202
- UniProt ID
- Q9Y6Q9
- Sequence Similarities
- Belongs to the SRC/p160 nuclear receptor coactivator family.
- Cellular Localization
- Cytoplasm; Nucleus
- Post Translation Modifications
- Acetylated by CREBBP.
Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.
( Q9Y6Q9-NCOA3_HUMAN )
Methylated by CARM1. ( Q9Y6Q9-NCOA3_HUMAN )
Phosphorylated by IKK complex.
Regulated its function.
- Protein Refseq
- NP_001167558.1; NP_001167559.1; NP_006525.2; NP_858045.1
- Function
- Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion.
Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin.
Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs).
Displays histone acetyltransferase activity.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1024-FY194. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "NCOA3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2199z | Mouse Anti-NCOA3 Recombinant Antibody (clone 37A2) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG1 |
| MOB-0086CT | Recombinant Mouse anti-Human NCOA3 Monoclonal antibody (0.U.209) | IHC-P, IP, WB | |
| ZG-0305C | Mouse Anti-NCOA3 Recombinant Antibody (ZG-0305C) | WB, ELISA | Mouse IgG |
| VS3-XY1144 | Mouse Anti-NCOA3 Recombinant Antibody (clone 5H3) | ELISA, WB | Mouse IgG2b |
| VS3-XY1145 | Mouse Anti-NCOA3 Recombinant Antibody (clone 2C11B12) | ELISA, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2383 | Hi-Affi™ Recombinant Rabbit Anti-NCOA3 Monoclonal Antibody (DS2383AB) | WB, IHC, ICC, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4714 | Anti-NCOA3 Immunohistochemistry Kit | IHC |
See Our Custom Production in Action
Popular Products
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: FC, IHC, FuncS, Inhib, Cyt
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
