Anti-NCOA3 (clone W24V194) Recombinant Antibody Coupled Liposome (VS-1024-FY194) (CAT#: VS-1024-FY194)

• Potential Clinical Applications
• Melanoma

• Clone
• W24V194

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant mouse monoclonal antibody engineered to specifically bind to nuclear receptor coactivator 3 (NCOA3). NCOA3 is an essential protein that serves as a coactivator for numerous nuclear receptors, playing a significant role in transcriptional regulation and cellular signaling pathways. The ability of this antibody to selectively target NCOA3 allows researchers to study its function in cancer biology and other diseases, potentially paving the way for novel therapeutic strategies that modulate its activity.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• NCOA3

• Introduction
• The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.

• Alternative Names
• Nuclear Receptor Coactivator 3; Thyroid Hormone Receptor Activator Molecule 1; Receptor-Associated Coactivator 3; Class E Basic Helix-Loop-Helix Protein 42; Steroid Receptor Coactivator Protein 3; Amplified In Breast Cancer 1 Protein; CBP-Interacting Protein; EC 2.3.1.48; BHLHe42; TRAM-1; AIB-1; SRC-3; AIB1

• Full Name
• Nuclear Receptor Coactivator 3

• Gene ID
• 8202

• UniProt ID
• Q9Y6Q9

• Sequence Similarities
• Belongs to the SRC/p160 nuclear receptor coactivator family.

• Cellular Localization
• Cytoplasm; Nucleus

• Post Translation Modifications
• Acetylated by CREBBP.
  Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.
  ( Q9Y6Q9-NCOA3_HUMAN )
  Methylated by CARM1. ( Q9Y6Q9-NCOA3_HUMAN )
  Phosphorylated by IKK complex.
  Regulated its function.

• Protein Refseq
• NP_001167558.1; NP_001167559.1; NP_006525.2; NP_858045.1

• Function
• Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion.
  Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin.
  Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs).
  Displays histone acetyltransferase activity.

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