Anti-NCOR2 Antibody Prodrug, Protease Activated (VS-1025-YC93)
CAT#: VS-1025-YC93
The Anti-NCOR2 Antibody Prodrug, Protease Activated (VS-1025-YC93) is an antibody prodrug comprised of a recombinant mouse antibody targeting human NCOR2, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to NCOR2 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to NCOR2 effectively. NCOR2 (Nuclear Receptor Corepressor 2), also known as SMRT, is a corepressor that acts as a tumor suppressor by recruiting transcriptional repression complexes to various nuclear receptors. Its loss of function or decreased expression is associated with poor prognosis in cancers like prostate cancer, as the removal of this corepressor leads to the abnormal transcription of pro-growth genes.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1928/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows moderate nuclear positivity in Purkinje cells, cells in molecular layer and cells in granular layer.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1928/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1928/6321_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1928/6321_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1928/6321_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1928/6321_A_5_6.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196498-NCOR2
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Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human NCOR2
- Target
- NCOR2
- Species Reactivity
- Human
- Isotype
- IgG
- Epitope
- QRTWRSRCASWP
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.
- Alternative Names
- SMRT; TRAC; CTG26; SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; SMRTE-tau
- Gene ID
- 9612
- UniProt ID
- Q9Y618
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Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "NCOR2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1306MZ | Recombinant Mouse Anti-Human NCOR2 Antibody (clone 2653) | ELISA, IHC-Fr, WB | Mouse antibody |
| HPAB-0028-CN | Mouse Anti-NCOR2 Recombinant Antibody (HPAB-0028-CN) | ELISA, IHC, IP, IF, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0028-CN-S(P) | Mouse Anti-NCOR2 Recombinant Antibody; scFv Fragment (HPAB-0028-CN-S(P)) | ELISA, IHC, IP, IF, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0028-CN-F(E) | Mouse Anti-NCOR2 Recombinant Antibody; Fab Fragment (HPAB-0028-CN-F(E)) | ELISA, IHC, IP, IF, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY335 | Mouse Anti-NHP NCOR2 Recombinant Antibody (clone 1212) | WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1466 | Anti-NCOR2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4716 | Anti-Human NCOR2 Immunohistochemistry Kit | IHC |
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