Anti-NUCB2 (clone NAP37) Recombinant Antibody Coupled Liposome (VS-1024-FY302) (CAT#: VS-1024-FY302)
Anti-Nucb2 antibody conjugated liposomes hold significant potential in prostate cancer research by enabling targeted delivery of therapeutic agents directly to cancer cells expressing the Nucb2 antigen, thereby enhancing treatment efficacy while minimizing off-target effects. Additionally, these liposomes can serve as valuable tools for diagnostic applications, facilitating the visualization and tracking of prostate cancer progression in vivo.
More Infomation
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8395/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8395/if_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15931/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15931/if_selected.jpg
Figure 3 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8395/ihc_selected.jpg
(Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8395/ihc_selected.jpg
Figure 4 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15931/672_G1_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15931/672_G1_1_blue_red_green.jpg
Figure 5 Cerebral cortex
(Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8395/23609_B_8_5.jpg
(Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8395/23609_B_8_5.jpg
Figure 6 Salivary gland
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15931/34847_B_2_1.jpg
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15931/34847_B_2_1.jpg
Figure 7 Colon
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15931/34847_A_9_3.jpg
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15931/34847_A_9_3.jpg
Figure 8 Testis
(Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8395/23609_A_6_6.jpg
(Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8395/23609_A_6_6.jpg
Figure 9 Lymph node
(Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15931/34847_A_9_8.jpg
(Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15931/34847_A_9_8.jpg
Figure 10 RNA cell line category: Cell line enhanced (HL-60)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000070081-NUCB2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000070081-NUCB2
Specifications
- Potential Clinical Applications
- Prostate cancer
Product Composition
- Clone
- NAP37
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This antibody is a recombinant mouse monoclonal that was specifically engineered to target Nucb2. It is designed to recognize and bind with high affinity to Nucb2, facilitating various research applications. By utilizing this monoclonal antibody, researchers can gain deeper insights into the biological functions of Nucb2 in cellular processes and disease mechanisms.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- NUCB2
- Introduction
- Nesfatin-1 is a neuropeptide produced in the hypothalamus of mammals. It participates in the regulation of hunger and fat storage. Increased nesfatin-1 in the hypothalamus contributes to diminished hunger, a 'sense of fullness', and a potential loss of body fat and weight.
- Alternative Names
- Nesfatin-1
- Full Name
- Nucleobindin 2
- Gene ID
- 4925
- UniProt ID
- P80303
- Sequence Similarities
- Belongs to the nucleobindin family.
- Cellular Localization
- Golgi apparatus; Membrane; Peripheral membrane protein; Cytoplasm; Secreted; Endoplasmic reticulum; Nucleus envelope
- Post Translation Modifications
- Glycosylation at Ser42, Ser96, Thr163, Thr172, Thr314, Thr322, Tyr389, and Ser408 ( NX_P80303 [NX_P80303-1] )
Ubiquitination at Lys90 and Lys247 ( NX_P80303 [NX_P80303-1] )
Modification sites at PhosphoSitePlus ( P80303 )
Glycosylation from GlyGen (P80303) 11 sites, 3 O-linked glycans (10 sites)
- Protein Refseq
- XP_016873301.1; XP_016873302.1; XP_016873303.1; XP_016873306.1; XP_016873307.1
- Function
- Calcium-binding protein which may have a role in calcium homeostasis (By similarity).
Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity).
Downloads
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Single Domain Antibody Products
IgG Antibody Products
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1826-sdAb | Recombinant Anti-Human Nucb2 VHH Single Domain Antibody | ICC, FC, WB, FUNC | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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