Anti-PSAP (clone W24V315) Recombinant Antibody Coupled Liposome (VS-1024-FY304)
CAT#: VS-1024-FY304
Anti-PSAP antibody conjugated liposomes hold significant potential in prostate cancer research by enabling targeted delivery of therapeutic agents directly to cancer cells, thereby enhancing treatment efficacy while minimizing off-target effects. Additionally, the use of these liposomes can facilitate the imaging of prostate tumors, improving diagnostics and monitoring responses to therapies.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4426/if_selected.jpg
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More Infomation
Specifications
- Potential Clinical Applications
- Prostate cancer
Product Composition
- Clone
- W24V315
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that has been specifically tailored to recognize and bind to the prolyl endopeptidase, PSAP. This antibody is instrumental for research applications aimed at elucidating the role of PSAP in cellular signaling and dysfunction. By employing this precise molecular tool, scientists can advance their understanding of PSAP's contributions to various physiological and pathological processes.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- PSAP
- Introduction
- This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites.
- Alternative Names
- GLBA; SAP1; SAP2; PSAPD; PARK24
- Full Name
- Prosaposin
- Gene ID
- 5660
- UniProt ID
- P07602
- Cellular Localization
- Secreted
- Post Translation Modifications
- The lysosomal precursor is proteolytically processed to 4 small peptides, which are similar to each other and are sphingolipid hydrolase activator proteins. ( P07602-SAP_HUMAN )
N-linked glycans show a high degree of microheterogeneity. ( P07602-SAP_HUMAN )
The one residue extended Saposin-B-Val is only found in 5% of the chains. ( P07602-SAP_HUMAN )
Glycosylation at Asn80, Asn101, Asn136, Thr214, Asn215, Ser216, Thr217, Asn332, Thr397, Thr401, and Asn426 ( NX_P07602 [NX_P07602-1] )
Modification sites at PhosphoSitePlus ( P07602 )
Glycosylation from GlyConnect SAP_HUMAN (1645)
Glycosylation from GlyGen (P07602) 22 sites, 297 N-linked glycans (7 sites), 4 O-linked glycans (15 sites)
- Protein Refseq
- NP_001035930.1; NP_001035931.1; NP_002769.1
- Function
- Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46).
Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "PSAP"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-1068 | Recombinant Mouse Anti-Human PSAP Antibody Fab Fragment | ELISA | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L072S | TX14A-Sap immunotoxin | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1640CT | Recombinant Mouse anti-Human PSAP Monoclonal antibody (EML642) | IHC-P, WB | |
| MOB-281YJL | Rabbit Anti-PSAP Recombinant Antibody (clone CBP266) | ELISA | Rabbit IgG |
| VS3-XY1311 | Mouse Anti-PSAP Recombinant Antibody (clone 4D5F4) | IHC, ICC | Mouse IgG2b |
| VS7-0425-WR697 | Mouse Anti-PSAP Recombinant Antibody (clone 3B4A8) | WB, IHC, ICC, FC | Mouse IgG1 |
| VS7-0425-WR698 | Mouse Anti-PSAP Recombinant Antibody (clone 3A5H7) | WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2881 | Hi-Affi™ Recombinant Rabbit Anti-PSAP Monoclonal Antibody (DS2881AB) | WB, IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1770 | Anti-PSAP Immunohistochemistry Kit | IHC | |
| VS-0525-XY5760 | Anti-Human PSAP Immunohistochemistry Kit | IHC |
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