DrugMonitor™ Rabbit Anti-Sirna-027 Antibody (VS-0125-YC1737)
CAT#: VS-0125-YC1737
Sirna-027 is a chemically modified short interfering RNA (siRNA) targeting the Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1), under Phase I trials for macular degeneration treatment. This product is the DrugMonitor™ Anti-Sirna-027 Antibody (VS-0125-YC1737), specifically designed as an anti-drug antibody (ADA) that targets Sirna-027. The ADA was raised in rabbits immunized with Sirna-027 conjugated to BSA and is suitable for use in ELISA and lateral flow assays. This antibody may be employed in pharmacokinetics (PK) and pharmacodynamics (PD) analyses, or as a reference standard in ADA assays. Furthermore, as a drug-based antibody, it serves as an exemplary tool for therapeutic drug monitoring, facilitating the determination of Sirna-027 drug concentrations in various samples.
Specifications
- Host Animal
- Rabbit
- Specificity
- Sirna-027
- Target
- Sirna-027
- Immunogen
- Sirna-027 conjugated to BSA
- Type
- Rabbit IgG
- Purity
- >95%
- Purification
- Protein G purified
- Conjugate
- Unconjugated
- Applications
- ELISA, Lateral Flow, PK/PD, ADA Control
- Format
- BSA and Azide Free. This formulation is ideal for antibody labeling (e.g. fluorophores, enzymes, small drugs, and oligonucleotides) and functional assays (e.g. In vitro and In vivo).
- Buffer
- PBS, pH 7.2
- Preservative
- No preservatives
- Storage
- Store at 4°C for 1-2 weeks and at -20°C for 1 year. Avoid repeated freezing and thawing.
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Essential For siRNA Therapeutic Analysis
Detecting chemically modified siRNA like Sirna-027 can be difficult, but this antibody worked very well. We used it in a pharmacodynamic study to track the drug's presence, and the results were consistent with the expected receptor blockage activity in our models.
Versatile For Different Assay Types
The formulation being free of BSA and azide allowed us to label this antibody for a custom lateral flow assay. It bound specifically to the target siRNA, making it a versatile tool for our therapeutic drug monitoring development projects.
Q&As
-
Can you describe the target molecule Sirna-027?
A: Sirna-027 is a chemically modified short interfering RNA (siRNA) that targets the Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1). It has been under investigation in Phase I trials for the treatment of macular degeneration.
-
Is this antibody suitable for developing lateral flow assays?
A: Yes, this antibody is suitable for use in lateral flow assays, as well as ELISA. It is supplied unconjugated in a PBS buffer that is BSA and Azide Free, which is ideal for the labeling often required in such assay development.
View the frequently asked questions answered by Creative Biolabs Support.
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