AbPlus™ Anti-SMYD2 Magnetic Beads (D294) (CAT#: VS-0424-XY242)

• Applications
• Immunoprecipitation, Immunoprecipitation-Mass Spectrometry

• Matrix
• Magrose bead (> 50 μmol/mL gel)

• Bead Ligand
• Anti-SMYD2 specific antibody (D294)

• Target
• SMYD2

• Immunogen
• SMYD2 protein

• Target Species
• Human

• Antibody Clone
• D294

• Bead Capacity
• 20-30 mg/mL binding antibody

• Bead size
• 10-37 μm

• Stability
• pH 2-14

• Format
• 20% Suspension

• Buffer
• PBS, pH 7.4, with 1% BSA

• Preservative
• 0.03% Proclin 300

• Storage
• Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

• Application Notes
• The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

• Introduction
• Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 Lys-4 (H3K4me) and dimethylates histone H3 Lys-36 (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates Lys-370 of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates Lys-860 of RB1/RB.

• Alternative Names
• SMYD2; SET and MYND domain containing 2; KMT3C; HSKM-B; ZMYND14; N-lysine methyltransferase SMYD2; SET and MYND domain-containing protein 2; histone methyltransferase SMYD2; lysine N-methyltransferase 3C; zinc finger, MYND domain containing 14

• Gene ID
• 56950

• UniProt ID
• Q9NRG4

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