Anti-SOX10 Antibody Prodrug, Protease Activated (VS-1025-YC135)
CAT#: VS-1025-YC135
The Anti-SOX10 Antibody Prodrug, Protease Activated (VS-1025-YC135) is an antibody prodrug comprised of a recombinant mouse antibody targeting human SOX10, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to SOX10 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to SOX10 effectively. SOX10 is essential for neural crest development and serves as a highly specific diagnostic marker for melanoma and certain nerve sheath tumors. However, its overexpression can also act as an oncogene by promoting cell proliferation and survival in these same tumor types.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68898/1371_E3_1_selected.jpg
Normal Tissue
Figure 2 High expression in cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3171/9957_B_9_5.jpg
Normal Tissue
Figure 3 Salivary gland
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3171/9957_B_1_1.jpg
Normal Tissue
Figure 4 Colon
Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3171/9957_A_8_3.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (SK-MEL-30, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000100146-SOX10
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Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human SOX10
- Target
- SOX10
- Species Reactivity
- Human
- Isotype
- IgG1, kappa
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein G purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
- Alternative Names
- DOM; WS4; PCWH; WS2E; WS4C
- Gene ID
- 6663
- UniProt ID
- P56693
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "SOX10"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3576z | Mouse Anti-SOX10 Recombinant Antibody (clone 19D12) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3374 | Hi-Affi™ Recombinant Rabbit Anti-SOX10 Monoclonal Antibody (DS3374AB) | WB, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-083CN | Mouse Anti-SOX10 Recombinant Antibody (NS-083CN) | WB, ELISA, ICC, IHC | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-083CN-F(E) | Mouse Anti-SOX10 Recombinant Antibody; Fab Fragment (NS-083CN-F(E)) | WB, ELISA, ICC, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-083CN-S(P) | Mouse Anti-SOX10 Recombinant Antibody; scFv Fragment (NS-083CN-S(P)) | WB, ELISA, ICC, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1422-CN | Recombinant Mouse Anti-SOX10 Monoclonal Antibody (1-11) | WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1423-CN | Recombinant Rabbit Anti-SOX10 Monoclonal Antibody (CBACN-520) | WB, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1424-CN | Recombinant Rabbit Anti-SOX10 Monoclonal Antibody (CBACN-521) | WB, IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0398U | Rabbit Anti-SOX10 Recombinant Antibody (clone I25-T) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2148 | Anti-SOX10 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6815 | Anti-Mouse SOX10 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6814 | Anti-Human SOX10 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6816 | Anti-Rat SOX10 Immunohistochemistry Kit | IHC |
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