AbPlus™ Anti-TFPI2 Magnetic Beads (VS-0724-YC763) (CAT#: VS-0724-YC763)

• Applications
• Immunoprecipitation, Protein Purification

• Matrix
• Magnetic bead

• Bead Ligand
• Anti-TFPI2 specific antibody

• Target
• TFPI2

• Immunogen
• Recombinant human TAB1 fragment derived from E. coli.

• Target Species
• Human

• Bead Capacity
• 40 mg/mL

• Bead size
• 25 μm

• Format
• Suspension

• Concentration
• 2 mg/mL

• Buffer
• PBS, pH 7.4

• Preservative
• 0.1% Sodium azide

• Storage
• Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

• Application Notes
• The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

• Introduction
• The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

• Alternative Names
• TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1; TAK1-Binding Protein 1; Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1; Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 1; MAP3K7IP1; Transforming Growth Factor Beta-Activated Kinase-Binding Protein 1;

• Gene ID
• 10454

• UniProt ID
• Q15750

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