Human Anti-TRPV3 Recombinant Soluble TCR (clone FE5)
CAT#: scTCR-1190YC-S(P)
Recombinant Human single-chain TCR (scTCR) FE5 recognizes Transient receptor potential cation channel subfamily V member 3 (LLLNMLIAL) in the context of HLA-A2. The scTCR is responsible for the specificity of T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69550/1519_C2_1_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (A-431, BEWO, CACO-2, RH-30, T-47d, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000167723-TRPV3
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Specifications
- Host Species
- Human
- Target
- TRPV3
- Species Reactivity
- Human
- Epitope
- LLLNMLIAL
- MHC
- HLA-A2
- Clone
- FE5
- Type
- Single-Chain TCR
Target
- Alternative Names
- Transient Receptor Potential Cation Channel Subfamily V Member 3; Vanilloid Receptor-Like 3; VRL-3; Transient Receptor Potential Cation Channel, Subfamily V, Member 3; Vanilloid Receptor-Related Osmotically Activated Channel Protein; FNEPPK2; TrpV3; OLMS; VRL3
- Gene ID
- 162514
- UniProt ID
- Q8NET8
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Unique Target Specificity
Finding a soluble TCR that recognizes the TRPV3 cation channel was excellent for our sensory neuron research. The FE5 clone worked well with HLA-A2, helping us explore the role of this protein in temperature sensation pathways.
Good For Ion Channel Studies
We used this product to investigate the recognition of the LLLNMLIAL peptide. It provided reliable binding data in our assays, which is contributing to our understanding of nonselective cation channels and their transcript variants.
Q&As
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What is the function of the protein recognized by this TCR?
A: The target protein, TRPV3, belongs to a family of nonselective cation channels. It functions in various processes, including temperature sensation and vasoregulation, and is activated at distinct physiological temperatures between 22 and 40 degrees Celsius.
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Which peptide sequence does the FE5 clone recognize?
A: The FE5 clone provided in this product recognizes the peptide sequence LLLNMLIAL. This sequence is derived from the Transient Receptor Potential Cation Channel Subfamily V Member 3 and is recognized in the context of HLA-A2.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Datasheet
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COA
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See other products for "Clone FE5"
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- Product Name
See other products for "TRPV3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0387MZ | Recombinant Mouse Anti-Human Transient Receptor Potential Cation Channel, Subfamily V, Member 3 Antibody (clone T16-5) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2374 | Anti-TRPV3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7560 | Anti-Mouse TRPV3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-FY95 | Mouse Anti-TRPV3 Recombinant Antibody (clone 2506W56) | WB, IHC, ICC, IF, IP | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7559 | Anti-Human TRPV3 Immunohistochemistry Kit | IHC |
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